Ciprofloxacin

162 interactions 10 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Brexpiprazole Famotidine Metformin Galantamine Ifosfamide Injection Oxaliplatin Injection
133 Major 29 Moderate
All (162) Major (133) Moderate (29)

Moderate

Ciprofloxacin Abemaciclib Verzenio Explained Increased abemaciclib plasma concentration Details Ciprofloxacin Aspirin Acuprin® An increased risk of convulsions Details Ciprofloxacin Aspirin Rectal Aspirin An increased risk of convulsions Details Ciprofloxacin Avanafil Stendra Increased avanafil exposure Details Ciprofloxacin Bromfenac Ophthalmic Bromday® An increased risk of convulsions Details Ciprofloxacin Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of convulsions Details Ciprofloxacin Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of convulsions Details Ciprofloxacin Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of convulsions Details Ciprofloxacin Diclofenac Transdermal Patch Flector An increased risk of convulsions Details Ciprofloxacin Dutasteride Avodart Increase in dutasteride plasma concentrations Details Ciprofloxacin Etodolac Lodine An increased risk of convulsions Details Ciprofloxacin Fenoprofen Fenopron An increased risk of convulsions Details Ciprofloxacin Flurbiprofen Ansaid An increased risk of convulsions Details Ciprofloxacin Flurbiprofen Ophthalmic Ocufen An increased risk of convulsions Details Ciprofloxacin Ibuprofen Addaprin An increased risk of convulsions Details Ciprofloxacin Ketoprofen Actron® An increased risk of convulsions Details Ciprofloxacin Ketorolac Acular An increased risk of convulsions Details Ciprofloxacin Ketorolac Injection Acular An increased risk of convulsions Details Ciprofloxacin Ketorolac Nasal Spray Sprix An increased risk of convulsions Details Ciprofloxacin Ketorolac Ophthalmic Acular An increased risk of convulsions Details Ciprofloxacin Lanthanum Fosrenol® Reduced bioavailability of quinolone antibiotics Details Ciprofloxacin Levothyroxine Ermeza Decreased efficacy of levothyroxine Details Ciprofloxacin Meclofenamate Meclodium® An increased risk of convulsions Details Ciprofloxacin Mefenamic Acid Ponstel® An increased risk of convulsions Details Ciprofloxacin Meloxicam Alloxate An increased risk of convulsions Details Ciprofloxacin Meloxicam Injection Alloxate An increased risk of convulsions Details Ciprofloxacin Nabumetone Relafen An increased risk of convulsions Details Ciprofloxacin Naproxen Aleve An increased risk of convulsions Details Ciprofloxacin Patiromer Veltassa Reduced ciprofloxacin exposure and reduced efficacy of ciprofloxacin Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.