Clindamycin Topical

Name: Clindamycin Topical Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

78 interactions 680 cited references

Also sold as: C/T/S® Cleocin-T® Clinda-Derm® Clindagel® Clindets® Evoclin®

About Clindamycin Topical

Topical clindamycin is used to treat acne. Clindamycin is in a class of medications called lincomycin antibiotics. It works by slowing or stopping the growth of bacteria that cause acne and by decreasing swelling. Read the full Clindamycin Topical drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mifepristone Levoketoconazole Ensitrelvir Voriconazole Lefamulin Lazertinib

3 Contraindicated 57 Major 18 Moderate

All (78) Contraindicated (3) Major (57) Moderate (18)

Contraindicated

Clindamycin Topical Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Clindamycin Topical Levoketoconazole Recorlev Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Clindamycin Topical Mifepristone Korlym Increased CYP3A4 substrate with NTI exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.