Clindamycin Topical

78 interactions 680 cited references
Also sold as: C/T/S® Cleocin-T® Clinda-Derm® Clindagel® Clindets® Evoclin®
About Clindamycin Topical

Topical clindamycin is used to treat acne. Clindamycin is in a class of medications called lincomycin antibiotics. It works by slowing or stopping the growth of bacteria that cause acne and by decreasing swelling. Read the full Clindamycin Topical drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mifepristone Levoketoconazole Ensitrelvir Voriconazole Lefamulin Lazertinib
3 Contraindicated 57 Major 18 Moderate
All (78) Contraindicated (3) Major (57) Moderate (18)

Moderate

Clindamycin Topical Artemether Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Clindamycin Topical Atracurium Enhanced and prolonged neuromuscular blockade Details Clindamycin Topical Cisatracurium Enhanced neuromuscular blocking action Details Clindamycin Topical Cyclosporine Atopica Decreased cycloSPORINE bioavailability Details Clindamycin Topical Doxacurium Enhanced and prolonged neuromuscular blockade Details Clindamycin Topical Gallamine Enhanced and prolonged neuromuscular blockade Details Clindamycin Topical Kaolin Pet Pectillin Decreased clindamycin effectiveness Details Clindamycin Topical Kratom Increased CYP3A substrate exposure Details Clindamycin Topical Lixisenatide Delayed therapeutic effect Details Clindamycin Topical Mavacamten Camzyos Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Clindamycin Topical Metocurine Enhanced and prolonged neuromuscular blockade Details Clindamycin Topical Mivacurium Enhanced and prolonged neuromuscular blockade Details Clindamycin Topical Pancuronium Pancuronium toxicity (respiratory depression) Details Clindamycin Topical Pipecuronium Enhanced and prolonged neuromuscular blockade Details Clindamycin Topical Rilzabrutinib Wayrilz Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Clindamycin Topical Rocuronium Enhanced and prolonged neuromuscular blockade Details Clindamycin Topical Tubocurarine Enhanced and prolonged neuromuscular blockade Details Clindamycin Topical Vecuronium Vecuronium toxicity (respiratory depression) Details

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