Clopidogrel

359 interactions 1 explained in plain English 501 cited references
Also sold as: Plavix Plavix®
About Clopidogrel

Clopidogrel is an antiplatelet medication used to prevent heart attacks and strokes in people with heart disease or poor circulation. Read the full Clopidogrel drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Clopidogrel Carbamazepine Carbatrol Increased clopidogrel active metabolite exposure, and an increased platelet inhibition and reduced clopidogrel exposure Details Clopidogrel Celecoxib Celebrex An increased risk of bleeding Details Clopidogrel Certoparin Increased risk of bleeding Details Clopidogrel Choline Salicylate An increased risk of bleeding Details Clopidogrel Cilostazol Pletal® An increased risk of bleeding Details Clopidogrel Citalopram Celexa An increased risk of bleeding Details Clopidogrel Clevidipine Decreased antiplatelet effect and increased risk of thrombotic events Details Clopidogrel Clonixin An increased risk of bleeding Details Clopidogrel Cobicistat Tybost Potential reduction of the antiplatelet activity of clopidogrel Details Clopidogrel Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) Reduced efficacy of clopidogrel Details Clopidogrel Curcumin An increased risk of bleeding Details Clopidogrel Dabigatran Etexilate An increased risk of bleeding Details Clopidogrel Dalteparin Fragmin Increased risk of bleeding Details Clopidogrel Danaparoid Increased risk of bleeding Details Clopidogrel Daprodustat Jesduvroq Increased daprodustat exposure Details Clopidogrel Darunavir Reduced clopidogrel active metabolite exposure Details Clopidogrel Desirudin Iprivask Increased risk of bleeding Details Clopidogrel Desloratadine Clarinex Increased desloratadine exposure Details Clopidogrel Desvenlafaxine Pristiq An increased risk of bleeding Details Clopidogrel Dexibuprofen An increased risk of bleeding Details Clopidogrel Dexketoprofen An increased risk of bleeding Details Clopidogrel Diacetylmorphine Reduced efficacy of clopidogrel Details Clopidogrel Diclofenac Aleve Arthritis Pain An increased risk of bleeding Details Clopidogrel Difenoxin Reduced efficacy of clopidogrel Details Clopidogrel Diflunisal Dolobid An increased risk of bleeding Details Clopidogrel Dihydrocodeine Reduced efficacy of clopidogrel Details Clopidogrel Diltiazem Cardizem Decreased antiplatelet effect and increased risk of thrombotic events Details Clopidogrel Diphenoxylate Reduced efficacy of clopidogrel Details Clopidogrel Dipyridamole Permole® An increased risk of bleeding Details Clopidogrel Dipyrone An increased risk of bleeding Details Clopidogrel Droxicam An increased risk of bleeding Details Clopidogrel Duloxetine An increased risk of bleeding Details Clopidogrel Edoxaban Savaysa Increased risk of bleeding Details Clopidogrel Enoxaparin Lovenox Increased risk of bleeding Details Clopidogrel Epoprostenol Flolan An increased risk of bleeding Details Clopidogrel Eptifibatide Increased risk of bleeding Details Clopidogrel Escitalopram Lexapro An increased risk of bleeding Details Clopidogrel Esomeprazole Nexium Reduced clopidogrel active metabolite exposure and reduced antiplatelet activity Details Clopidogrel Ethylmorphine Reduced efficacy of clopidogrel Details Clopidogrel Etodolac Lodine An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.