Clopidogrel

359 interactions 1 explained in plain English 501 cited references
Also sold as: Plavix Plavix®
About Clopidogrel

Clopidogrel is an antiplatelet medication used to prevent heart attacks and strokes in people with heart disease or poor circulation. Read the full Clopidogrel drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Clopidogrel Piketoprofen An increased risk of bleeding Details Clopidogrel Piracetam Increased risk of bleeding Details Clopidogrel Piritramide Reduced efficacy of clopidogrel Details Clopidogrel Piroxicam Feldene An increased risk of bleeding Details Clopidogrel Prasugrel Effient An increased risk of bleeding Details Clopidogrel Primidone Mysoline Reduced CYP2C19 substrate exposure and reduced efficacy of CYP2C19 substrate Details Clopidogrel Proglumetacin An increased risk of bleeding Details Clopidogrel Propyphenazone An increased risk of bleeding Details Clopidogrel Proquazone An increased risk of bleeding Details Clopidogrel Protein C Ceprotin Increased risk of bleeding Details Clopidogrel Remibrutinib Rhapsido An increased risk of bleeding Details Clopidogrel Remifentanil Reduced efficacy of clopidogrel Details Clopidogrel Repaglinide Prandin® Increased repaglinide exposure Details Clopidogrel Resmetirom Rezdiffra Increased resmetirom exposure and an increased risk of resmetirom-related adverse reactions Details Clopidogrel Reviparin Increased risk of bleeding Details Clopidogrel Rifampin Rifadin Increased clopidogrel active metabolite exposure and an increased platelet inhibition Details Clopidogrel Ritonavir Norvir Altered clopidogrel active metabolite exposure and an increased platelet inhibition Details Clopidogrel Rivaroxaban Xarelto An increased risk of bleeding Details Clopidogrel Rofecoxib An increased risk of bleeding Details Clopidogrel Salicylic Acid An increased risk of bleeding Details Clopidogrel Salsalate Disalcid An increased risk of bleeding Details Clopidogrel Selexipag Uptravi Increased exposure of selexipag and its active metabolite and an increased risk of bleeding Details Clopidogrel Selumetinib Koselugo Increased risk of bleeding Details Clopidogrel Sibutramine Increased risk of bleeding Details Clopidogrel Sodium Salicylate An increased risk of bleeding Details Clopidogrel Sufentanil Dsuvia Reduced efficacy of clopidogrel Details Clopidogrel Sulfinpyrazone An increased risk of bleeding Details Clopidogrel Sulindac Clinoril® An increased risk of bleeding Details Clopidogrel Sulodexide Increased risk of bleeding Details Clopidogrel Tapentadol Nucynta Reduced efficacy of clopidogrel Details Clopidogrel Tenecteplase An increased risk of bleeding Details Clopidogrel Tenoxicam An increased risk of bleeding Details Clopidogrel Tiaprofenic Acid An increased risk of bleeding Details Clopidogrel Ticagrelor Brilinta Increased risk of bleeding Details Clopidogrel Ticlopidine Ticlid® Reduced clopidogrel active metabolite exposure, reduced platelet inhibition and an increased risk of bleeding Details Clopidogrel Tilidine Reduced efficacy of clopidogrel Details Clopidogrel Tinzaparin Increased risk of bleeding Details Clopidogrel Tirofiban An increased risk of bleeding Details Clopidogrel Tolfenamic Acid An increased risk of bleeding Details Clopidogrel Tolmetin Tolectin 600 An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.