Clopidogrel

359 interactions 1 explained in plain English 501 cited references

Also sold as: Plavix Plavix®

About Clopidogrel

Clopidogrel is an antiplatelet medication used to prevent heart attacks and strokes in people with heart disease or poor circulation. Read the full Clopidogrel drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Abrocitinib Defibrotide Darunavir Nalbuphine Injection Methotrexate Injection

3 Contraindicated 239 Major 115 Moderate 2 Minor

All (359) Contraindicated (3) Major (239) Moderate (115) Minor (2)

Moderate

Clopidogrel Eslicarbazepine Acetate Aptiom Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Estetrol Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Estradiol Delestrogen Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Ethinyl Estradiol Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Ethynodiol Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Etonogestrel Nexplanon Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Etravirine Intelence Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Evening Primrose Increased risk of bleeding Details Clopidogrel Fedratinib Inrebic Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Felbamate Felbatol Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Feverfew Increased risk of bleeding Details Clopidogrel Fexinidazole Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Fluconazole Diflucan Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Fluvastatin Lescol An increased risk of fluvastatin toxicity (dyspepsia, abdominal pain, nausea, diarrhea, muscle weakness, myalgias, muscle tenderne... Details Clopidogrel Garlic Increased risk of bleeding and reduced clopidogrel active metabolite exposure Details Clopidogrel Gestodene Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Ginkgo Increased clopidogrel and clopidogrel active metabolite exposure and increased platelet inhibition which may increase the risk of... Details Clopidogrel Givosiran Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Guggul Increased risk of bleeding Details Clopidogrel Hawthorn Increased risk of bleeding Details Clopidogrel Ibritumomab Tiuxetan An increased risk of bleeding and hemorrhage Details Clopidogrel Icosapent Ethyl Vascepa An increased risk of bleeding Details Clopidogrel Iloprost Aurlumyn Increased risk of bleeding Details Clopidogrel Isoniazid Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Kava Increased risk of bleeding Details Clopidogrel Lansoprazole Prevacid Reduced antiplatelet activity Details Clopidogrel Lecanemab-Irmb An increased risk of amyloid related imaging abnormalities or intracerebral hemorrhage Details Clopidogrel Letermovir Prevymis Increased clopidogrel active metabolite exposure and an increased platelet inhibition Details Clopidogrel Levonorgestrel After banger Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Licorice Increased risk of bleeding Details Clopidogrel Lovastatin Altocor® Decreased formation of clopidogrel active metabolite resulting in high on-treatment platelet reactivity Details Clopidogrel Meadowsweet Increased risk of bleeding Details Clopidogrel Medroxyprogesterone Amen® Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Mestranol Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Moclobemide Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Modafinil Provigil Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Motherwort Increased risk of bleeding Details Clopidogrel Nomegestrol Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Norelgestromin Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Norethindrone Aygestin Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details

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