Clopidogrel

359 interactions 1 explained in plain English 501 cited references

Also sold as: Plavix Plavix®

About Clopidogrel

Clopidogrel is an antiplatelet medication used to prevent heart attacks and strokes in people with heart disease or poor circulation. Read the full Clopidogrel drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Abrocitinib Defibrotide Darunavir Nalbuphine Injection Methotrexate Injection

3 Contraindicated 239 Major 115 Moderate 2 Minor

All (359) Contraindicated (3) Major (239) Moderate (115) Minor (2)

Moderate

Clopidogrel Norgestimate Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Norgestrel Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Obeticholic Acid Ocaliva Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Omega-3-Acid Ethyl Esters Lovaza Increased risk of bleeding Details Clopidogrel Omega-3-Carboxylic Acids Increased risk of bleeding Details Clopidogrel Osilodrostat Isturisa Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Oxcarbazepine Oxtellar Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Pentoxifylline Pentoxil® An increased risk of bleeding Details Clopidogrel Phenytoin Dilantin Increased clopidogrel active metabolite exposure and an increased platelet inhibition Details Clopidogrel Pioglitazone Actos Increased exposure of pioglitazone Details Clopidogrel Piperine Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Pirtobrutinib Jaypirca Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Rabeprazole Aciphex Reduced antiplatelet activity Details Clopidogrel Rolapitant Varubi Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Rucaparib Rubraca Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Segesterone Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Skullcap Increased risk of bleeding Details Clopidogrel Sparsentan Filspari Reduced CYP2C19 substrate exposure and reduced efficacy of CYP2C19 substrate Details Clopidogrel Stiripentol Diacomit Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel St John's Wort Increased clopidogrel active metabolite exposure and an increased platelet inhibition Details Clopidogrel Tan-Shen Increased risk of bleeding Details Clopidogrel Tazemetostat Tazverik Increased clopidogrel active metabolite exposure and an increased platelet inhibition Details Clopidogrel Tecovirimat Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Tipranavir Aptivus Increased clopidogrel active metabolite exposure and an increased platelet inhibition Details Clopidogrel Tocilizumab Actemra Increased clopidogrel active metabolite exposure and an increased platelet inhibition Details Clopidogrel Tolbutamide Orinase® An increased risk of hypoglycemia Details Clopidogrel Torsemide Soaanz An increased risk of torsemide toxicity (nausea, dizziness, headache, fatigue, skin rash, muscle cramps, and increases in serum ur... Details Clopidogrel Triclabendazole Egaten Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Ulipristal Ella Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Vitamin A Aquasol A Increased risk of bleeding Details Clopidogrel Estradiol Topical Divigel Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Estradiol Transdermal Patch Alora® Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Ibritumomab Injection Zevalin® An increased risk of bleeding and hemorrhage Details Clopidogrel Lecanemab-Irmb Injection Leqembi An increased risk of amyloid related imaging abnormalities or intracerebral hemorrhage Details Clopidogrel Letermovir Injection Prevymis Increased clopidogrel active metabolite exposure and an increased platelet inhibition Details Clopidogrel Levonorgestrel Intrauterine System Kyleena Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Clopidogrel Medroxyprogesterone Injection Depo-Provera Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details

Minor

Clopidogrel Arnica Increased risk of bleeding Details Clopidogrel Ginger Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.