Cobicistat

Contraindicated

Cobicistat Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Cobicistat Simvastatin Flolipid Explained Increased simvastatin exposure and an increased risk of simvastatin toxicity, including an increased risk of myopathy or rhabdomyo... Details Cobicistat Alfuzosin UroXatral Increased alfuzosin exposure Details Cobicistat Dihydroergotamine Injection DHE-45® Injection An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Cobicistat Dihydroergotamine Nasal Spray Migranal An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Cobicistat Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Cobicistat Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Cobicistat Irinotecan Camptosar Increased irinotecan exposure and an risk of increased irinotecan active metabolite exposure Details Cobicistat Irinotecan Injection Camptosar Increased irinotecan exposure and an risk of increased irinotecan active metabolite exposure Details Cobicistat Ivabradine Corlanor Increased ivabradine exposure and an increased risk of ivabradine-related adverse effects [like bradycardia and conduction disturb... Details Cobicistat Lovastatin Altocor® Increased risk of lovastatin toxicity and an increased risk of myopathy or rhabdomyolysis Details Cobicistat Lurasidone Latuda Increased lurasidone exposure and an increased cobicistat exposure Details Cobicistat Methylergonovine Methergine An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Cobicistat Midazolam Nasal Spray Nayzilam Increased midazolam plasma concentrations and increased risk for serious adverse effects including, prolonged or increased sedatio... Details Cobicistat Midazolam Injection Nayzilam Increased midazolam plasma concentrations and increased risk for serious adverse effects including, prolonged or increased sedatio... Details Cobicistat Naloxegol Movantik Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Cobicistat Nevirapine Viramune Reduced cobicistat exposure and an altered (reduced/increased) nevirapine exposure Details

Major

Cobicistat Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine exposure and increased or reduced active metabolite (morphine) exposure Details Cobicistat Abametapir Explained Increased exposure of CYP3A4 substrate Details Cobicistat Amitriptyline Elavil Explained Increased exposure of amitriptyline Details Cobicistat Sertraline Explained Increased sertraline exposure Details Cobicistat Buprenorphine Belbuca Explained Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Cobicistat Relugolix Orgovyx Explained Increased relugolix exposure Details Cobicistat Acalabrutinib Calquence Increased acalabrutinib exposure Details Cobicistat Ado-Trastuzumab Emtansine Injection KADCYLA Increased exposure of cytotoxic component DM1 (maytansine derivative) and risk of toxicity Details Cobicistat Alpelisib Piqray Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Cobicistat Apixaban Eliquis Explained Increased apixaban exposure and an increased risk of bleeding Details Cobicistat Aripiprazole Injection Abilify Increased ARIPiprazole exposure Details Cobicistat Asciminib Scemblix Increased asciminib exposure and an increased risk of asciminib-related adverse effects Details Cobicistat Atogepant Qulipta Increased atogepant exposure Details Cobicistat Avapritinib Ayvakit Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Cobicistat Betrixaban Bevyxxa® Increased betrixaban exposure and increased risk of bleeding Details Cobicistat Atorvastatin Atorvaliq Increased cobicistat exposure, an increased atorvastatin exposure and an increased risk of myopathy Details Cobicistat Cariprazine Vraylar Explained Increased exposure to cariprazine and its active metabolite, didesmethylcariprazine Details Cobicistat Afatinib Gilotrif Increased exposure of afatinib Details Cobicistat Amlodipine Amvaz® Increased amLODIPine exposure, an increased risk of hypotension and edema and an increased cobicistat exposure Details Cobicistat Avanafil Stendra Increased avanafil exposure and increased risk of avanafil-related adverse events Details Cobicistat Beclomethasone Nasal Spray Beconase Increased beclomethasone exposure and an increased risk of beclomethasone-related adverse reactions Details Cobicistat Beclomethasone Oral Inhalation Beclovent® Increased beclomethasone exposure and an increased risk of beclomethasone-related adverse reactions Details Cobicistat Bedaquiline Sirturo Increased bedaquiline exposure Details