Cobicistat

129 interactions 12 explained in plain English
Also sold as: Tybost
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lovastatin Lurasidone Methylergonovine Ivabradine Irinotecan Colchicine
17 Contraindicated 103 Major 9 Moderate
All (129) Contraindicated (17) Major (103) Moderate (9)

Contraindicated

Cobicistat Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Cobicistat Simvastatin Flolipid Explained Increased simvastatin exposure and an increased risk of simvastatin toxicity, including an increased risk of myopathy or rhabdomyo... Details Cobicistat Alfuzosin UroXatral Increased alfuzosin exposure Details Cobicistat Dihydroergotamine Injection DHE-45® Injection An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Cobicistat Dihydroergotamine Nasal Spray Migranal An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Cobicistat Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Cobicistat Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Cobicistat Irinotecan Camptosar Increased irinotecan exposure and an risk of increased irinotecan active metabolite exposure Details Cobicistat Irinotecan Injection Camptosar Increased irinotecan exposure and an risk of increased irinotecan active metabolite exposure Details Cobicistat Ivabradine Corlanor Increased ivabradine exposure and an increased risk of ivabradine-related adverse effects [like bradycardia and conduction disturb... Details Cobicistat Lovastatin Altocor® Increased risk of lovastatin toxicity and an increased risk of myopathy or rhabdomyolysis Details Cobicistat Lurasidone Latuda Increased lurasidone exposure and an increased cobicistat exposure Details Cobicistat Methylergonovine Methergine An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Cobicistat Midazolam Nasal Spray Nayzilam Increased midazolam plasma concentrations and increased risk for serious adverse effects including, prolonged or increased sedatio... Details Cobicistat Midazolam Injection Nayzilam Increased midazolam plasma concentrations and increased risk for serious adverse effects including, prolonged or increased sedatio... Details Cobicistat Naloxegol Movantik Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Cobicistat Nevirapine Viramune Reduced cobicistat exposure and an altered (reduced/increased) nevirapine exposure Details

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