Cobicistat

Name: Cobicistat Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

129 interactions 12 explained in plain English

Also sold as: Tybost

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lovastatin Lurasidone Methylergonovine Ivabradine Irinotecan Colchicine

17 Contraindicated 103 Major 9 Moderate

All (129) Contraindicated (17) Major (103) Moderate (9)

Moderate

Cobicistat Abemaciclib Verzenio Explained Increased abemaciclib plasma concentration Details Cobicistat Atenolol Tenormin Explained Increased antiarrhythmic exposure Details Cobicistat Acebutolol Sectral® Increased antiarrhythmic exposure Details Cobicistat Atropine Ophthalmic Atropine Care 1% Increased antiarrhythmic exposure Details Cobicistat Dofetilide Tikosyn Increased dofetilide exposure and an increased risk of dofetilide-related adverse effects Details Cobicistat Esmolol Brevibloc Increased antiarrhythmic exposure Details Cobicistat Flecainide Tambocor® Increased flecainide exposure Details Cobicistat Guanfacine Intuniv Increased guanfacine exposure Details Cobicistat Mexiletine Mexitil® Increased mexiletine exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.