Cobicistat

Major

Cobicistat Cyclophosphamide Injection Cytoxan® Injection Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cobicistat Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased cobicistat exposure Details Cobicistat Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased cobicistat exposure Details Cobicistat Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Cobicistat Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Cobicistat Dasatinib Phyrago Increased dasatinib exposure and an increased risk of dasatinib-related adverse effects Details Cobicistat Deflazacort Emflaza Increased exposure to active metabolite of deflazacort Details Cobicistat Dexamethasone Injection Decadron Reduced cobicistat exposure and increased dexAMETHasone exposure Details Cobicistat Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced cobicistat exposure and increased dexAMETHasone exposure Details Cobicistat Diazepam Nasal Spray Valtoco Increased diazepam exposure Details Cobicistat Diazepam Rectal Diastat Increased diazepam exposure Details Cobicistat Didanosine Videx® Increased risk of adverse effects Details Cobicistat Digoxin Cardoxin® Increased digoxin exposure Details Cobicistat Disopyramide Norpace Increased disopyramide exposure Details Cobicistat Docetaxel Beizray Increased DOCEtaxel exposure Details Cobicistat Docetaxel Injection Beizray Increased DOCEtaxel exposure Details Cobicistat Edoxaban Savaysa Increased edoxaban exposure Details Cobicistat Elacestrant Orserdu Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Cobicistat Encorafenib Braftovi Increased encorafenib exposure and an increased risk of encorafenib-related adverse events Details Cobicistat Entrectinib Rozlytrek Increased entrectinib exposure and an increased frequency or severity of adverse reactions Details Cobicistat Erdafitinib Balversa Increased erdafitinib exposure Details Cobicistat Erlotinib Tarceva Increased erlotinib exposure and risk of toxicity Details Cobicistat Everolimus Afinitor Increased everolimus exposure and an increased cobicistat exposure Details Cobicistat Felodipine Plendil® Increased calcium channel blocker exposure and an increased risk of calcium channel blocker-related adverse effects Details Cobicistat Fentanyl Transdermal Patch Duragesic® Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Cobicistat Fluvastatin Lescol Increased HMG-CoA reductase inhibitor that also are OATP1B1/B3 substrates exposure Details Cobicistat Futibatinib Lytgobi Increased futibatinib exposure and increased risk of futibatinib-related adverse reactions Details Cobicistat Gilteritinib Xospata Increased gilteritinib plasma concentrations Details Cobicistat Glasdegib Daurismo Increased glasdegib exposure Details Cobicistat Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Cobicistat Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Cobicistat Ibrexafungerp Brexafemme Increased ibrexafungerp exposure Details Cobicistat Ibrutinib Imbruvica Increased ibrutinib exposure Details Cobicistat Ifosfamide Injection Ifex Decreased ifosfamide effectiveness Details Cobicistat Infigratinib Truseltiq Increased infigratinib plasma concentrations Details Cobicistat Istradefylline Nourianz Increased istradefylline exposure Details Cobicistat Ixabepilone Injection IXEMPRA Increased ixabepilone exposure and increase in the incidence and severity of adverse reactions Details Cobicistat Ketoconazole Topical Extina® Foam Increased cobicistat exposure and an increased ketoconazole exposure Details Cobicistat Lefamulin Xenleta Increased lefamulin exposure and an increased risk of lefamulin-related adverse reactions Details Cobicistat Lenacapavir Injection Sunlenca Increased lenacapavir exposure Details