Cobicistat

129 interactions 12 explained in plain English
Also sold as: Tybost
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Cobicistat Lenacapavir Oral Sunlenca Increased lenacapavir exposure Details Cobicistat Leniolisib Joenja Increased leniolisib exposure Details Cobicistat Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Cobicistat Loperamide Diamode An increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Cobicistat Lumateperone Caplyta Increased lumateperone exposure, an increased risk of lumateperone-related adverse reactions, an increased cobicistat exposure and... Details Cobicistat Lurbinectedin Injection Zepzelca Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Cobicistat Macitentan Opsumit Increased macitentan exposure Details Cobicistat Maraviroc Selzentry Increased maraviroc exposure Details Cobicistat Midostaurin Rydapt Increased midostaurin exposure Details Cobicistat Mirvetuximab Soravtansine-Gynx Injection Elahere Increased unconjugated DM4 exposure and an increased risk of mirvetuximab soravtansine-gynx adverse reactions Details Cobicistat Mitapivat Aqvesme Increased mitapivat exposure and an increased risk of mitapivat-related adverse reactions Details Cobicistat Mometasone Asmanex Increased mometasone exposure and an increased risk for systemic corticosteroid effects Details Cobicistat Mometasone Nasal Spray Nasonex Increased mometasone exposure and an increased risk for systemic corticosteroid effects Details Cobicistat Mometasone Oral Inhalation Asmanex Increased mometasone exposure and an increased risk for systemic corticosteroid effects Details Cobicistat Mometasone Topical Elocon® Increased mometasone exposure and an increased risk for systemic corticosteroid effects Details Cobicistat Morphine Injection Astramorph® PF Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Cobicistat Nebivolol Bystolic Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Cobicistat Neratinib Nerlynx Increased neratinib exposure and risk of toxicity Details Cobicistat Nifedipine Adalat® Increased NIFEdipine exposure and an increased risk of hypotension, bradycardia, or acute renal injury Details Cobicistat Nimodipine Nimotop Increased risk of significant hypotension Details Cobicistat Nisoldipine Sular Increased nisoldipine exposure Details Cobicistat Olaparib Lynparza Increased olaparib exposure Details Cobicistat Orlistat Alli Reduced efficacy of antiretrovirals, loss of virological control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.