Colestipol

50 interactions 158 cited references

Also sold as: Colestid Colestid® Colestid® Flavored Granules Colestid® Granules

About Colestipol

Colestipol is a bile acid sequestrant used to lower LDL cholesterol levels in people with high cholesterol. Read the full Colestipol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bezafibrate Chenodiol Deferasirox Digoxin Elafibranor Ezetimibe

14 Major 29 Moderate 7 Minor

All (50) Major (14) Moderate (29) Minor (7)

Major

Colestipol Bezafibrate Decreased bezafibrate efficacy Details Colestipol Chenodiol Reduced chenodiol exposure and reduced efficacy of chenodiol Details Colestipol Deferasirox Exjade Decreased deferasirox concentrations Details Colestipol Digoxin Cardoxin® Reduced digoxin exposure Details Colestipol Elafibranor Iqirvo Reduced elafibranor exposure and reduced efficacy of elafibranor Details Colestipol Ezetimibe Zetia Reduced ezetimibe exposure and reduced efficacy of ezetimibe Details Colestipol Fenofibrate Antara Reduced absorption of fenofibrate Details Colestipol Fenofibric Acid Fibricor Reduced absorption of fenofibrate Details Colestipol Linerixibat Reduced exposure of linerixibat and reduced efficacy of linerixibat Details Colestipol Lomitapide Reduced lomitapide exposure Details Colestipol Mycophenolate Mofetil Reduced exposure of mycophenolic acid (MPA) and reduced efficacy of mycophenolate mofetil Details Colestipol Mycophenolic Acid Myfortic Reduced mycophenolic acid exposure Details Colestipol Seladelpar Reduced seladelpar exposure and reduced efficacy of seladelpar Details Colestipol Taurursodiol Reduced exposure of taurursodiol Details

Moderate

Colestipol Aceclofenac Decreased diclofenac bioavailability Details Colestipol Cholic Acid Decreased efficacy of cholic acid Details Colestipol Diclofenac Aleve Arthritis Pain Decreased diclofenac bioavailability Details Colestipol Diltiazem Cardizem Decreased diltiazem bioavailability Details Colestipol Estetrol Decreased estetrol and drospirenone exposure Details Colestipol Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Colestipol Furosemide Disal Decreased furosemide effectiveness Details Colestipol Hydrochlorothiazide Inzirqo Decreased hydrochlorothiazide concentration Details Colestipol Hydrocortisone Ala-Cort Decreased hydrocortisone effectiveness Details Colestipol Levothyroxine Ermeza Reduced efficacy of levothyroxine and an increased risk of hypothyroidism Details Colestipol Liothyronine Cytomel Decreased effectiveness of liothyronine Details Colestipol Maralixibat Livmarli Reduced exposure and efficacy of maralixibat Details Colestipol Obeticholic Acid Ocaliva Reduced exposure and efficacy of obeticholic acid Details Colestipol Odevixibat Bylvay Reduced exposure and efficacy of odevixibat Details Colestipol Potassium Phosphate K-Phos Decreased phosphate absorption Details Colestipol Potassium Phosphate, Dibasic Decreased phosphate absorption Details Colestipol Potassium Phosphate, Monobasic Decreased phosphate absorption Details Colestipol Pravastatin Pravachol Reduced effectiveness of pravastatin Details Colestipol Propranolol Hemangeol Decreased propranolol effectiveness Details Colestipol Sodium Phosphate OsmoPrep Decreased phosphate absorption Details Colestipol Sodium Phosphate, Dibasic Decreased phosphate absorption Details Colestipol Sodium Phosphate, Monobasic Decreased phosphate absorption Details Colestipol Tetracycline Achromycin V® Decreased tetracycline effectiveness Details Colestipol Diclofenac Ophthalmic Voltaren® Eye Drops Decreased diclofenac bioavailability Details Colestipol Diclofenac Topical (Actinic Keratosis) Pennsaid Decreased diclofenac bioavailability Details Colestipol Diclofenac Topical (Arthritis Pain) Pennsaid® Decreased diclofenac bioavailability Details

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