Conjugated / Estrogens

Name: Conjugated / Estrogens Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

5 interactions

Also sold as: Premarin

Read the full Conjugated / Estrogens drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Hydroxychloroquine Ketoconazole Topical

2 Major 3 Moderate

All (5) Major (2) Moderate (3)

Major

Conjugated / Estrogens Hydroxychloroquine Plaquenil An increased risk of seizures Details Conjugated / Estrogens Ketoconazole Topical Extina® Foam Increased conjugated estrogens exposure and an increased risk of conjugated estrogens-related adverse effects Details

Moderate

Conjugated / Estrogens Levothyroxine Ermeza Reduced serum-free thyroxine exposure Details Conjugated / Estrogens Lonapegsomatropin-Tcgd Injection Skytrofa Reduced lonapegsomatropin-tcgd efficacy Details Conjugated / Estrogens Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.