Dacomitinib

56 interactions 1 explained in plain English 55 cited references
Also sold as: Vizimpro Vizimpro®
About Dacomitinib

Dacomitinib is used to treat a certain type of non-small-cell lung cancer (NSCLC) that has spread to other parts of the body. Dacomitinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the sprea… Read the full Dacomitinib drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mumps Virus Vaccine, Live Dengue Tetravalent Vaccine, Live Measles Virus Vaccine, Live Pimozide Rubella Virus Vaccine, Live Smallpox Monkeypox Vaccine
10 Contraindicated 43 Major 3 Moderate
All (56) Contraindicated (10) Major (43) Moderate (3)

Contraindicated

Dacomitinib Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Dacomitinib Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Dacomitinib Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Dacomitinib Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Dacomitinib Pimozide Increased pimozide exposure Details Dacomitinib Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Dacomitinib Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Dacomitinib Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Dacomitinib Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Dacomitinib Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Dacomitinib Omeprazole Gastrobim Reduced dacomitinib exposure Details Dacomitinib Aripiprazole Injection Abilify Increased ARIPiprazole exposure Details Dacomitinib Brexpiprazole Rexulti Increased brexpiprazole exposure Details Dacomitinib Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Dacomitinib Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Dacomitinib Amphetamine Dexedrine Increased amphetamine exposure and increased risk of serotonin syndrome Details Dacomitinib Aripiprazole Abilify Increased ARIPiprazole exposure Details Dacomitinib Aripiprazole Lauroxil Aristada Increased ARIPiprazole exposure Details Dacomitinib Atomoxetine Atoncy Increased atomoxetine exposure and an increased risk of atomoxetine-related adverse reactions Details Dacomitinib Benzphetamine Increased amphetamine exposure and increased risk of serotonin syndrome Details Dacomitinib Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Dacomitinib Clomipramine Anafranil Increased clomiPRAMINE exposure Details Dacomitinib Desipramine Norpramin Increased exposure of the CYP2D6 substrate Details Dacomitinib Dexlansoprazole Dexilant Reduced dacomitinib exposure Details Dacomitinib Dextroamphetamine Dexedrine Increased amphetamine exposure and increased risk of serotonin syndrome Details Dacomitinib Doxepin Prudoxin Increased doxepin exposure and an increased risk of doxepin-related adverse reactions Details Dacomitinib Duloxetine Increased DULoxetine exposure and an increased risk of DULoxetine-related adverse effects Details Dacomitinib Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Dacomitinib Esomeprazole Nexium Reduced dacomitinib exposure Details Dacomitinib Flecainide Tambocor® Increased exposure of the CYP2D6 substrate Details Dacomitinib Fluoxetine RECONCILE Increased FLUoxetine exposure and an increased risk of QT interval prolongation Details Dacomitinib Haloperidol Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Dacomitinib Hydroxyamphetamine Increased amphetamine exposure and increased risk of serotonin syndrome Details Dacomitinib Imipramine Increased exposure of the CYP2D6 substrate Details Dacomitinib Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Dacomitinib Lansoprazole Prevacid Reduced dacomitinib exposure Details Dacomitinib Lisdexamfetamine Arynta Increased amphetamine exposure and increased risk of serotonin syndrome Details Dacomitinib Methamphetamine Desoxyn Increased amphetamine exposure and increased risk of serotonin syndrome Details Dacomitinib Mexiletine Mexitil® Increased exposure of the CYP2D6 substrate Details Dacomitinib Milsaperidone Increased milsaperidone exposure and an increased risk of milsaperidone-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.