Drug Interaction Report

Danazol and Cyclosporine Ophthalmic: Interaction Details

A pharmacist-reviewed analysis of the Danazol and Cyclosporine Ophthalmic interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Cyclosporine Ophthalmic

Cequa Cequa® Restasis® Vevye
+

Danazol

Danocrine®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 28 documented Danazol interactions, 7 are rated moderate — including this one.
Onset
delayed
Evidence
probable
Severity
Moderate

What happens

Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias)

Interaction Deep Dive

Concomitant administration of cycloSPORINE and anabolic steroids may result in increased cycloSPORINE blood levels12 and toxicity. This effect has been observed in 2 case studies with methyltestosterone and in 1 case study with danazol 345. Adjust cycloSPORINE dosage to achieve the desired cycloSPORINE concentrations when these drugs are administered concomitantly 12.

Why it happens (mechanism)

Decreased cycloSPORINE metabolism

Literature reports

1 report — tap to read

a) Concomitant administration of cycloSPORINE and anabolic steroids may result in increased cycloSPORINE blood levels and toxicity. This effect has been observed in 2 case studies with methyltestosterone and in 1 case study with danazol 345.

Common questions

Can I take Danazol and Cyclosporine Ophthalmic together?

Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Always confirm with your pharmacist or prescriber before making any change.

How serious is the Danazol and Cyclosporine Ophthalmic interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "delayed". Effects tend to build up gradually over days to weeks.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

Questions for your pharmacist

  • Does my dose of Danazol or Cyclosporine Ophthalmic need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (5)

  1. Product Information: NEORAL(R) oral soft gelatin capsules oral solution, cyclosporine modified oral soft gelatin capsules oral solution. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2023. DailyMed
  2. Product Information: SANDIMMUNE(R) oral capsules, oral solution, intravenous injection, cyclosporine oral capsules, oral solution, intravenous injection. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2023. DailyMed
  3. Moller BB & Ekelun B: Toxicity of cyclosporine during treatment with androgen (letter). N Engl J Med 1985; 133:1416.
  4. Goffin E, Pirson Y, Geubel A, et al: Cyclosporine-methyltestosterone interaction. Nephron 1991; 59:174-175. PubMed
  5. Ross WB, Roberts D, & Griffin PJ: Cyclosporin interaction with danazol and norethisterone (letter). Lancet 1986; 1:330. DOI
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Cyclosporine Ophthalmic

Keep reading about Cyclosporine Ophthalmic

All Cyclosporine Ophthalmic interactions (545) Cyclosporine Ophthalmic drug information
Also serious with: Dronedarone Elagolix Ensitrelvir Ezetimibe
Danazol

Keep reading about Danazol

All Danazol interactions (28) Danazol drug information
Also serious with: Simvastatin Ezetimibe Methotrexate Injection Fluvastatin
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Danazol + Activated Charcoal Adrafinil Alfalfa Angelica Archangelica Arrach Bergamot Bishop's Weed Cannabidiol (cbd) + 42 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.