Darunavir

Name: Darunavir Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

115 interactions 11 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lovastatin Lurasidone Ivabradine Methylergonovine Colchicine Maraviroc

13 Contraindicated 89 Major 13 Moderate

All (115) Contraindicated (13) Major (89) Moderate (13)

Major

Darunavir Nafcillin Injection Unipen® Injection Decreased darunavir exposure Details Darunavir Nebivolol Bystolic Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Darunavir Nevirapine Viramune Decreased darunavir exposure Details Darunavir Nicardipine Cardene Increased calcium channel blocker exposure and an increased risk of calcium channel blocker-related adverse effects Details Darunavir Nimodipine Nimotop Increased calcium channel blocker exposure and an increased risk of calcium channel blocker-related adverse effects Details Darunavir Olaparib Lynparza Increased olaparib exposure Details Darunavir Olutasidenib Rezlidhia Reduced sensitive CYP3A substrate exposure Details Darunavir Orlistat Alli Reduced efficacy of antiretrovirals, loss of virological control Details Darunavir Penbutolol Levatol® Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.