Dasabuvir and Cyclosporine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Cyclosporine Injection
Dasabuvir
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased cycloSPORINE concentrations; increased dasabuvir concentrations
Interaction Deep Dive
Concomitant use of dasabuvir (a BCRP and P-gp substrate) and cycloSPORINE (a BCRP and P-gp inhibitor) may result in increased concentrations of both drugs. When initiating dasabuvir therapy, reduce the cycloSPORINE dose to one-fifth of the current dose, and make further dosing modifications based on cycloSPORINE levels. Monitor for renal dysfunction and other adverse events associated with both agents with concurrent use. If dasabuvir is discontinued, readjust the cycloSPORINE dose based on cycloSPORINE blood levels1.
Why it happens (mechanism)
Unknown mechanism; inhibition of dasabuvir BCRP and P-gp efflux transport
Common questions
Can I take Dasabuvir and Cyclosporine Injection together?
Increased cycloSPORINE concentrations; increased dasabuvir concentrations Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dasabuvir and Cyclosporine Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Dasabuvir or Cyclosporine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VIEKIRA PAK oral tablets, ombitasvir paritaprevir ritonavir oral tablets and dasabuvir oral tablets. AbbVie Inc. (per manufacturer), North Chicago, Il, 2014.
Keep reading about Cyclosporine Injection
Keep reading about Dasabuvir
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