Drug Interaction Report

Dasatinib and Cimetidine: Interaction Details

A pharmacist-reviewed analysis of the Dasatinib and Cimetidine interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Cimetidine

Tagamet
+

Dasatinib

Phyrago Sprycel Sprycel®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
LinkedIn
Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 342 documented Dasatinib interactions, 297 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Reduced dasatinib exposure

Interaction Deep Dive

Avoid coadministration of dasatinib and histamine-2 receptor antagonists as this may result in decreased dasatinib exposure. Coadministration of dasatinib and famotidine (a histamine-2 receptor antagonist) resulted in 61% and 63% decrease in dasatinib AUC and Cmax, respectively. Consider the use of antacids in place of the histamine-2 receptor antagonist2.

Why it happens (mechanism)

Inhibition of gastric acid

Literature reports

2 reports — tap to read

a) Following a dose of famotidine (a histamine-2 receptor antagonist), the administration of dasatinib 10 hours later resulted in a 61% and 63% reduction in mean dasatinib AUC and Cmax, respectively 2.

b) No clinically significant differences in the pharmacokinetics of dasatinib were observed following concomitant use with famotidine (H2 receptor antagonist) 1.

Common questions

Can I take Dasatinib and Cimetidine together?

Reduced dasatinib exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Dasatinib and Cimetidine interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Dasatinib or Cimetidine need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (2)

  1. Product Information: PHYRAGO oral tablets, dasatinib oral tablets. Nanocopoeia, LLC (per FDA), New Brighton, MN, 2023. DailyMed
  2. Product Information: SPRYCEL(R) oral tablets, dasatinib oral tablets. Bristol-Myers Squibb Company (per FDA), Princeton, NJ, 2023. DailyMed
Was this write-up helpful?
Cimetidine

Keep reading about Cimetidine

All Cimetidine interactions (83)
Also serious with: Colchicine Dofetilide Metformin Octreotide Injection
Dasatinib

Keep reading about Dasatinib

All Dasatinib interactions (342) Dasatinib drug information
Also serious with: Bacillus Of Calmette And Guerin Vaccine, Live Sparfloxacin Thioridazine Terfenadine
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Cimetidine + Activated Charcoal Pu-erh Tea St. John's Wort Adrafinil African Wild Potato Banderol Beer Bitter Melon + 87 more
Dasatinib + Activated Charcoal American Hellebore Arsenic Cesium Ephedra Grapefruit Sida Cordifolia St. John's Wort + 138 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

Check another combination

Our instant two-drug interaction checker is almost here.

Coming soon

The instant two-drug checker is on its way.

In the meantime, browse the directory below to look up any drug and see its documented interactions.

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.