Drug Interaction Report

Dasatinib and Mitotane: Interaction Details

A pharmacist-reviewed analysis of the Dasatinib and Mitotane interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Mitotane

Lysodren
+

Dasatinib

Phyrago Sprycel Sprycel®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 342 documented Dasatinib interactions, 297 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
probable
Severity
Major

What happens

Reduced dasatinib exposure and reduced efficacy of dasatinib

Interaction Deep Dive

Treatment with dasatinib and a strong CYP3A4 inducer may result in decreased dasatinib concentrations and should be avoided. When coadministered with rifAMPin, a strong CYP3A4 inducer, dasatinib mean Cmax and AUC decreased by 81% and 82%, respectively. If used concomitantly, consider an increased dose of dasatinib and monitor for toxicity2. Consider alternative drugs with less enzyme induction potential 1.

Why it happens (mechanism)

Induction of CYP3A4-mediated dasatinib metabolism

Literature reports

1 report — tap to read

a) The coadministration of rifAMPin once daily, a strong CYP3A4 inducer, decreased dasatinib mean Cmax by 81% and mean AUC by 82% 21.

Common questions

Can I take Dasatinib and Mitotane together?

Reduced dasatinib exposure and reduced efficacy of dasatinib Always confirm with your pharmacist or prescriber before making any change.

How serious is the Dasatinib and Mitotane interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

Questions for your pharmacist

  • Does my dose of Dasatinib or Mitotane need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (2)

  1. Product Information: PHYRAGO oral tablets, dasatinib oral tablets. Nanocopoeia, LLC (per FDA), New Brighton, MN, 2023. DailyMed
  2. Product Information: SPRYCEL(R) oral tablets, dasatinib oral tablets. Bristol-Myers Squibb Company (per FDA), Princeton, NJ, 2023. DailyMed
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Mitotane

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Dasatinib

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All Dasatinib interactions (342) Dasatinib drug information
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Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Mitotane + Activated Charcoal Coffee Charcoal European Mandrake Glucomannan Guar Gum Gum Arabic Slippery Elm Tragacanth + 9 more
Dasatinib + Activated Charcoal American Hellebore Arsenic Cesium Ephedra Grapefruit Sida Cordifolia St. John's Wort + 138 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.