Desmopressin

73 interactions 4 explained in plain English

Also sold as: DDAVP Desmoda Nocdurna Noctiva

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Difluprednate Ophthalmic Mometasone Topical Furosemide Injection Dexamethasone Ophthalmic Flunisolide Nasal Spray Desonide

37 Contraindicated 36 Moderate

All (73) Contraindicated (37) Moderate (36)

Moderate

Desmopressin Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of water intoxication with hyponatremia Details Desmopressin Amitriptyline Elavil Explained Increased risk of water intoxication with hyponatremia Details Desmopressin Sertraline Explained Increased risk of water intoxication with hyponatremia Details Desmopressin Buprenorphine Belbuca Explained Increased risk of water intoxication with hyponatremia Details Desmopressin Aspirin Acuprin® Increased risk of water intoxication with hyponatremia Details Desmopressin Aspirin Rectal Aspirin Increased risk of water intoxication with hyponatremia Details Desmopressin Bromfenac Ophthalmic Bromday® Increased risk of water intoxication with hyponatremia Details Desmopressin Butorphanol Injection Butorphic Increased risk of water intoxication with hyponatremia Details Desmopressin Butorphanol Nasal Spray Stadol® NS Increased risk of water intoxication with hyponatremia Details Desmopressin Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of water intoxication with hyponatremia Details Desmopressin Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of water intoxication with hyponatremia Details Desmopressin Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of water intoxication with hyponatremia Details Desmopressin Diclofenac Transdermal Patch Flector Increased risk of water intoxication with hyponatremia Details Desmopressin Etodolac Lodine Increased risk of water intoxication with hyponatremia Details Desmopressin Fenoprofen Fenopron Increased risk of water intoxication with hyponatremia Details Desmopressin Fentanyl Transdermal Patch Duragesic® Increased risk of water intoxication with hyponatremia Details Desmopressin Flurbiprofen Ansaid Increased risk of water intoxication with hyponatremia Details Desmopressin Flurbiprofen Ophthalmic Ocufen Increased risk of water intoxication with hyponatremia Details Desmopressin Glimepiride Amaryl Increased risk of water intoxication with hyponatremia Details Desmopressin Glipizide Glucotrol Increased risk of water intoxication with hyponatremia Details Desmopressin Hydromorphone Injection Dilaudid Increased risk of water intoxication with hyponatremia Details Desmopressin Hydromorphone Rectal available generically Increased risk of water intoxication with hyponatremia Details Desmopressin Ibuprofen Addaprin Increased risk of water intoxication with hyponatremia Details Desmopressin Ketoprofen Actron® Increased risk of water intoxication with hyponatremia Details Desmopressin Ketorolac Acular Increased risk of water intoxication with hyponatremia Details Desmopressin Ketorolac Injection Acular Increased risk of water intoxication with hyponatremia Details Desmopressin Ketorolac Nasal Spray Sprix Increased risk of water intoxication with hyponatremia Details Desmopressin Ketorolac Ophthalmic Acular Increased risk of water intoxication with hyponatremia Details Desmopressin Meclofenamate Meclodium® Increased risk of water intoxication with hyponatremia Details Desmopressin Mefenamic Acid Ponstel® Increased risk of water intoxication with hyponatremia Details Desmopressin Meloxicam Alloxate Increased risk of water intoxication with hyponatremia Details Desmopressin Meloxicam Injection Alloxate Increased risk of water intoxication with hyponatremia Details Desmopressin Morphine Injection Astramorph® PF Increased risk of water intoxication with hyponatremia Details Desmopressin Nabumetone Relafen Increased risk of water intoxication with hyponatremia Details Desmopressin Nalbuphine Injection Nubain® Increased risk of water intoxication with hyponatremia Details Desmopressin Naproxen Aleve Increased risk of water intoxication with hyponatremia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.