Desogestrel

46 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colesevelam Amoxicillin Penicillin V Potassium Dexamethasone Ophthalmic Penicillin G Procaine Injection Cefprozil

40 Major 6 Moderate

All (46) Major (40) Moderate (6)

Major

Desogestrel Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Desogestrel Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Desogestrel Ampicillin Amcill® Decreased contraceptive effectiveness Details Desogestrel Ampicillin Injection Omnipen-N® Decreased contraceptive effectiveness Details Desogestrel Bexarotene Targretin Decreased contraceptive effectiveness Details Desogestrel Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Desogestrel Cefaclor Ceclor® Decreased contraceptive effectiveness Details Desogestrel Cefadroxil Duricef® Decreased contraceptive effectiveness Details Desogestrel Cefdinir Omnicef® Decreased contraceptive effectiveness Details Desogestrel Cefixime Suprax Decreased contraceptive effectiveness Details Desogestrel Cefprozil Cefzil® Decreased contraceptive effectiveness Details Desogestrel Ceftazidime Injection Fortaz Decreased contraceptive effectiveness Details Desogestrel Cefuroxime Injection Kefurox® Decreased contraceptive effectiveness Details Desogestrel Colesevelam Welchol Decreased contraceptive effectiveness Details Desogestrel Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Desogestrel Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Desogestrel Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Desogestrel Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Desogestrel Doxycycline Injection Acticlate Reduced efficacy of oral contraceptive Details Desogestrel Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Desogestrel Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Desogestrel Exenatide Injection Bydureon Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Desogestrel Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Desogestrel Hydrocortisone Ala-Cort Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Desogestrel Hydrocortisone Injection A-Hydrocort® Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Desogestrel Lixisenatide Injection Adlyxin® Decreased absorption of oral contraceptives Details Desogestrel Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Desogestrel Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Desogestrel Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Desogestrel Methylergonovine Methergine Increased methylergonovine exposure Details Desogestrel Minocycline Amzeeq Decreased contraceptive efficacy Details Desogestrel Minocycline Topical Amzeeq Decreased contraceptive efficacy Details Desogestrel Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Desogestrel Nafcillin Injection Unipen® Injection Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Desogestrel Nevirapine Viramune Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Desogestrel Nifedipine Adalat® Increased NIFEdipine exposure Details Desogestrel Octreotide Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Desogestrel Octreotide Injection Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Desogestrel Penicillin G Procaine Injection Bactracillin G Decreased contraceptive effectiveness Details Desogestrel Penicillin V Potassium Beepen-VK® Decreased contraceptive effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.