Desonide Topical

30 interactions 156 cited references
Also sold as: Desonate® Desowen DesOwen® Verdeso®
About Desonide Topical

Desonide is used to treat the redness, swelling, itching, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). Desonide is… Read the full Desonide Topical drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Mifepristone Aspirin Bemiparin Bupropion Carbamazepine
2 Contraindicated 19 Major 9 Moderate
All (30) Contraindicated (2) Major (19) Moderate (9)

Contraindicated

Desonide Topical Desmopressin DDAVP Increased risk of severe hyponatremia Details Desonide Topical Mifepristone Korlym An increased risk of autoimmune disorders and an increased risk of acute adrenal insufficiency, that may lead to exacerbation or d... Details

Major

Desonide Topical Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Desonide Topical Bemiparin Increased risk of bleeding Details Desonide Topical Bupropion Aplenzin Lowering of the seizure threshold Details Desonide Topical Carbamazepine Carbatrol Reduced corticosteroids exposure and reduced efficacy of corticosteroids Details Desonide Topical Cosyntropin False elevations of plasma cortisol levels Details Desonide Topical Ethinyl Estradiol Increased corticosteroid exposure Details Desonide Topical Fosphenytoin Cerebyx Reduced corticosteroid exposure Details Desonide Topical Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Desonide Topical Insulin Glargine, Recombinant Basaglar Reduced blood glucose lowering effect of insulin Details Desonide Topical Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Desonide Topical Lutetium Lu 177 Dotatate Decreased lutetium Lu 177 dotatate efficacy Details Desonide Topical Macimorelin False-positive or false-negative adult growth hormone deficiency diagnosis Details Desonide Topical Nadroparin Increased risk of bleeding Details Desonide Topical Phenytoin Dilantin Reduced corticosteroid exposure Details Desonide Topical Rabies Vaccine Imovax An inadequate immunological response to the vaccine, an increased risk of altered immunocompetence and reduced immune response to... Details Desonide Topical Relacorilant Lifyorli Reduced relacorilant exposure and reduced efficacy of relacorilant, reduced glucocorticoids exposure and reduced efficacy of gluco... Details Desonide Topical Sargramostim Leukine Increased myeloproliferative effects of sargramostim Details Desonide Topical Somatrogon-Ghla Reduced serum cortisol exposure, an increased risk of central (secondary) hypoadrenalism and attenuated growth-promoting effects o... Details Desonide Topical Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details

Moderate

Desonide Topical Auranofin Ridaura Increased risk of auranofin-related adverse effects Details Desonide Topical Gallium Ga 68 Dotatate Increased risk of false negative imaging Details Desonide Topical Indapamide An increased risk of hypokalemia Details Desonide Topical Insulin Afrezza Reduced blood glucose lowering effect of insulin Details Desonide Topical Insulin Lispro, Recombinant Admelog May decrease blood glucose lowering effect of insulin lispro Details Desonide Topical Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Desonide Topical Olodaterol Striverdi An increased risk of hypokalemia Details Desonide Topical Rotavirus Vaccine, Live An inadequate immunological response to the vaccine Details Desonide Topical Testosterone Androderm Increased risk of edema Details

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