Diazoxide

47 interactions 3 explained in plain English
Also sold as: Proglycem Vykat
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Furosemide Injection Ketoconazole Topical Buprenorphine Hydromorphone Rectal Flurbiprofen Ophthalmic Meclofenamate
38 Major 9 Moderate
All (47) Major (38) Moderate (9)

Major

Diazoxide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Diazoxide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Diazoxide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Diazoxide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Diazoxide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Diazoxide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Diazoxide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Enasidenib Idhifa Increased diazoxide exposure and an increased risk of diazoxide-related adverse reactions Details Diazoxide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Diazoxide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Furosemide Injection Disal An increased risk of hyperglycemia and hyperuricemia Details Diazoxide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Diazoxide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Diazoxide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Ketoconazole Topical Extina® Foam Increased diazoxide exposure and an increased risk of diazoxide-related adverse reactions Details Diazoxide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Lithium Carbonate Lithobid Lithium toxicity Details Diazoxide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Mexiletine Mexitil® Increased CYP1A2 substrate exposure and an increased risk of CYP1A2 substrate-related adverse reactions Details Diazoxide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Diazoxide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Diazoxide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.