Diazoxide and Enasidenib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Diazoxide
Enasidenib
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased diazoxide exposure and an increased risk of diazoxide-related adverse reactions
Interaction Deep Dive
Concomitant use of diazoxide (CYP1A2 substrate) with strong CYP1A2 inhibitors may increase diazoxide exposure, which may increase the frequency and/or severity of adverse reactions from diazoxide. If coadministered, dosage modification is required. All doses are based on weight and given orally once daily. For weight 20 to less than 30 kg, 25 mg/day weeks 1 through 4, 50 mg/day Weeks 5 and 6, target dosage, 75 mg/day. For weight 30 to less than 40 kg, 50 mg/day for weeks 1 and 2, then 100 mg/day for weeks 3 through 6, target dosage, 100 mg/day. For weight 40 to less than 65 kg, 50 mg/day for weeks 1 and 2, 100 mg/day for weeks 3 and 4, 150 mg/day for weeks 5 and 6, target dosage, 150 mg/day. For weight 65 to less than 100 kg, 100 mg/day for weeks 1 and 2, 150 mg/day for weeks 3 and 4, 200 mg/day for weeks 5 and 6, target dosage, 250 mg/day. For weight 100 to less than 135 kg, 100 mg/day for weeks 1 and 2, 200 mg/day for weeks 3 and 4, 250 mg/day for weeks 5 and 6, target dosage, 300 mg/day. For weight 135 kg or greater, 100 mg/day for weeks 1 and 2, 200 mg/day for weeks 3 and 4, 300 mg/day for weeks 5 and 6, target dosage, 325 mg/day. Based on clinical response, diazoxide may be titrated to a maximum recommended dosage of 3.6 mg/kg/day. Do not exceed diazoxide dosage of 325 mg per day. In a clinical study, coadministration of diazoxide and fluvoxaMINE (a strong CYP1A2 inhibitor) at an inhibitory dose increased single dose diazoxide Cmax by 17.5% and AUC(0 to inf) by 60% compared to the same parameter inf measured on single dose in the absence of fluvoxaMINE coadministration1.
Why it happens (mechanism)
Inhibition of CYP1A2-mediated metabolism of diazoxide
Literature reports
1 report — tap to read
a) In a clinical study, coadministration of diazoxide and fluvoxaMINE (a strong CYP1A2 inhibitor) at an inhibitory dose increased single dose diazoxide Cmax by 17.5% and AUC(0 to inf) by 60% compared to the same parameter inf measured on single dose in the absence of fluvoxaMINE coadministration 1.
Common questions
Can I take Diazoxide and Enasidenib together?
Increased diazoxide exposure and an increased risk of diazoxide-related adverse reactions Always confirm with your pharmacist or prescriber before making any change.
How serious is the Diazoxide and Enasidenib interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Diazoxide or Enasidenib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VYKAT(TM) XR oral extended-release tablets, diazoxide choline oral extended-release tablets. Soleno Therapeutics (per FDA), Redwood City, CA, 2025. DailyMed
Keep reading about Diazoxide
Keep reading about Enasidenib
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