Diclofenac Topical (Actinic Keratosis)

268 interactions 703 cited references

Also sold as: Pennsaid Solaraze® Gel

About Diclofenac Topical (Actinic Keratosis)

Diclofenac topical gel (Solaraze) is used to treat actinic keratosis (flat, scaly growths on the skin caused by too much sun exposure). Diclofenac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). The way diclofenac gel works to treat actinic keratosis is not known. Diclofenac is also a… Read the full Diclofenac Topical (Actinic Keratosis) drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Major

Diclofenac Topical (Actinic Keratosis) Deferiprone Ferriprox Decreased deferiprone clearance and increased deferiprone plasma concentrations Details Diclofenac Topical (Actinic Keratosis) Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Topical (Actinic Keratosis) Desipramine Norpramin An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Desirudin Iprivask An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Desvenlafaxine Pristiq An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Deutivacaftor Increased CYP2C9 substrate exposure Details Diclofenac Topical (Actinic Keratosis) Dexamethasone Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Topical (Actinic Keratosis) Dexketoprofen Increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Diazoxide Proglycem Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Dibenzepin An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Diflunisal Dolobid Increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Dipyridamole Permole® An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Dipyrone Increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Dothiepin An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Doxepin Prudoxin An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Doxifluridine Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Topical (Actinic Keratosis) Droxicam Increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Duloxetine An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Edoxaban Savaysa An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Diclofenac Topical (Actinic Keratosis) Enoxaparin Lovenox An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Eplerenone Inspra Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Epoprostenol Flolan An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Eptifibatide An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Escitalopram Lexapro An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Ethacrynic Acid Edecrin Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Etodolac Lodine Increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Etofenamate Increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Etoricoxib Increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Etozolin Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Felbinac Increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Fenoprofen Fenopron Increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Fepradinol Increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Feprazone Increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Feverfew Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects) Details Diclofenac Topical (Actinic Keratosis) Floctafenine Increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Flufenamic Acid Increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Topical (Actinic Keratosis) Fluoxetine RECONCILE An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Flurbiprofen Ansaid Increased risk of bleeding Details

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