Diclofenac Topical (Actinic Keratosis)
268 interactions 703 cited references
Also sold as:
Pennsaid
Solaraze® Gel
About Diclofenac Topical (Actinic Keratosis)
Diclofenac topical gel (Solaraze) is used to treat actinic keratosis (flat, scaly growths on the skin caused by too much sun exposure). Diclofenac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). The way diclofenac gel works to treat actinic keratosis is not known. Diclofenac is also a… Read the full Diclofenac Topical (Actinic Keratosis) drug information page →
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Aug 9, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Moderate
Diclofenac Topical (Actinic Keratosis) Acebutolol Sectral® Reduced antihypertensive effect Details Diclofenac Topical (Actinic Keratosis) Amiodarone Nexterone Increased exposure of diclofenac Details Diclofenac Topical (Actinic Keratosis) Aprepitant Aponvie Decreased exposure of diclofenac Details Diclofenac Topical (Actinic Keratosis) Atenolol Tenormin Reduced antihypertensive effect Details Diclofenac Topical (Actinic Keratosis) Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Actinic Keratosis) Azilsartan Medoxomil Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Actinic Keratosis) Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Actinic Keratosis) Betaxolol Betoptic S Reduced antihypertensive effect Details Diclofenac Topical (Actinic Keratosis) Bisoprolol Zebeta® Reduced antihypertensive effect Details Diclofenac Topical (Actinic Keratosis) Bosentan Decreased exposure of diclofenac Details Diclofenac Topical (Actinic Keratosis) Candesartan Atacand Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Actinic Keratosis) Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Actinic Keratosis) Carbamazepine Carbatrol Decreased exposure of diclofenac Details Diclofenac Topical (Actinic Keratosis) Carteolol Reduced antihypertensive effect Details Diclofenac Topical (Actinic Keratosis) Carvedilol Coreg Reduced antihypertensive effect Details Diclofenac Topical (Actinic Keratosis) Celiprolol Reduced antihypertensive effect Details Diclofenac Topical (Actinic Keratosis) Cholestyramine Prevalite Decreased diclofenac bioavailability Details Diclofenac Topical (Actinic Keratosis) Ciprofloxacin An increased risk of convulsions Details Diclofenac Topical (Actinic Keratosis) Colestipol Colestid Decreased diclofenac bioavailability Details Diclofenac Topical (Actinic Keratosis) Desmopressin DDAVP Increased risk of water intoxication with hyponatremia Details Diclofenac Topical (Actinic Keratosis) Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Actinic Keratosis) Enalaprilat Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Actinic Keratosis) Entacapone Comtan Increased diclofenac exposure Details Diclofenac Topical (Actinic Keratosis) Enzalutamide Xtandi Decreased exposure of diclofenac Details Diclofenac Topical (Actinic Keratosis) Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Actinic Keratosis) Esmolol Brevibloc Reduced antihypertensive effect Details Diclofenac Topical (Actinic Keratosis) Fluconazole Diflucan Increased exposure of diclofenac Details Diclofenac Topical (Actinic Keratosis) Fosaprepitant Emend Injection Decreased exposure of diclofenac Details Diclofenac Topical (Actinic Keratosis) Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Actinic Keratosis) Ginkgo An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Actinic Keratosis) Labetalol Normodyne® Reduced antihypertensive effect Details Diclofenac Topical (Actinic Keratosis) Levobunolol Betagan Reduced antihypertensive effect Details Diclofenac Topical (Actinic Keratosis) Levofloxacin Levaquin An increased risk of seizures Details Diclofenac Topical (Actinic Keratosis) Lisinopril Prinivil Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Actinic Keratosis) L-Methylfolate Decreased l-methylfolate efficacy Details Diclofenac Topical (Actinic Keratosis) Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Diclofenac Topical (Actinic Keratosis) Ma Huang Increased risk of developing gastric mucosal lesions Details Diclofenac Topical (Actinic Keratosis) Mavacamten Camzyos Reduced CYP2C9 substrate exposure and reduced efficacy of CYP2C9 substrate Details Diclofenac Topical (Actinic Keratosis) Metipranolol Reduced antihypertensive effect DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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