Diclofenac Topical (Actinic Keratosis)

Name: Diclofenac Topical (Actinic Keratosis) Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

268 interactions 703 cited references

Also sold as: Pennsaid Solaraze® Gel

About Diclofenac Topical (Actinic Keratosis)

Diclofenac topical gel (Solaraze) is used to treat actinic keratosis (flat, scaly growths on the skin caused by too much sun exposure). Diclofenac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). The way diclofenac gel works to treat actinic keratosis is not known. Diclofenac is also a… Read the full Diclofenac Topical (Actinic Keratosis) drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Lithium Levomilnacipran Levoketoconazole Lepirudin

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Contraindicated

Diclofenac Topical (Actinic Keratosis) Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.