Diclofenac Topical (Actinic Keratosis)

268 interactions 703 cited references

Also sold as: Pennsaid Solaraze® Gel

About Diclofenac Topical (Actinic Keratosis)

Diclofenac topical gel (Solaraze) is used to treat actinic keratosis (flat, scaly growths on the skin caused by too much sun exposure). Diclofenac is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). The way diclofenac gel works to treat actinic keratosis is not known. Diclofenac is also a… Read the full Diclofenac Topical (Actinic Keratosis) drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Lithium Levomilnacipran Levoketoconazole Lepirudin

1 Contraindicated 197 Major 70 Moderate

All (268) Contraindicated (1) Major (197) Moderate (70)

Contraindicated

Diclofenac Topical (Actinic Keratosis) Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Diclofenac Topical (Actinic Keratosis) Abciximab An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Acenocoumarol An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Amiloride Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Amineptine An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Amitriptyline Elavil An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Amitriptylinoxide An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Amoxapine An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Anagrelide Agrylin An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Apalutamide Erleada Reduced CYP2C9 substrates exposure Details Diclofenac Topical (Actinic Keratosis) Apixaban Eliquis An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Ardeparin An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Argatroban An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Diclofenac Topical (Actinic Keratosis) Azathioprine Azasan An increased risk of hepatotoxicity Details Diclofenac Topical (Actinic Keratosis) Bemetizide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Bemiparin An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Bendroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Benzthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Betrixaban Bevyxxa® An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Bivalirudin Angiomax An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Diclofenac Topical (Actinic Keratosis) Bumetanide Bumex Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Cangrelor Kengreal An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Diclofenac Topical (Actinic Keratosis) Ceritinib Zykadia Increased exposure of CYP2C9 substrate Details Diclofenac Topical (Actinic Keratosis) Certoparin An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Chlorothiazide Diuril Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Chlorthalidone Hemiclor Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Cilostazol Pletal® An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Citalopram Celexa An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Clomipramine Anafranil An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Clopamide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Clopidogrel Plavix An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Cyclopenthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Cyclosporine Atopica An increased risk of cycloSPORINE nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Cyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Diclofenac Topical (Actinic Keratosis) Dabigatran Etexilate An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Dalteparin Fragmin An increased risk of bleeding Details Diclofenac Topical (Actinic Keratosis) Danaparoid An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.