Dienogest

47 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colesevelam Penicillin V Potassium Lixisenatide Injection Cyclosporine Ophthalmic Penicillin G Procaine Injection Cefprozil

41 Major 6 Moderate

All (47) Major (41) Moderate (6)

Major

Dienogest Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Dienogest Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Dienogest Ampicillin Amcill® Decreased contraceptive effectiveness Details Dienogest Ampicillin Injection Omnipen-N® Decreased contraceptive effectiveness Details Dienogest Bexarotene Targretin Decreased contraceptive effectiveness Details Dienogest Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Dienogest Cefaclor Ceclor® Decreased contraceptive effectiveness Details Dienogest Cefadroxil Duricef® Decreased contraceptive effectiveness Details Dienogest Cefdinir Omnicef® Decreased contraceptive effectiveness Details Dienogest Cefixime Suprax Decreased contraceptive effectiveness Details Dienogest Cefprozil Cefzil® Decreased contraceptive effectiveness Details Dienogest Ceftazidime Injection Fortaz Decreased contraceptive effectiveness Details Dienogest Cefuroxime Injection Kefurox® Decreased contraceptive effectiveness Details Dienogest Colesevelam Welchol Decreased contraceptive effectiveness Details Dienogest Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Dienogest Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Dienogest Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Dienogest Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Dienogest Doxycycline Injection Acticlate Reduced efficacy of oral contraceptive Details Dienogest Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Dienogest Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Dienogest Exenatide Injection Bydureon Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Dienogest Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Dienogest Hydrocortisone Ala-Cort Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Dienogest Hydrocortisone Injection A-Hydrocort® Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Dienogest Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Dienogest Lixisenatide Injection Adlyxin® Decreased absorption of oral contraceptives Details Dienogest Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Dienogest Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Dienogest Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Dienogest Methylergonovine Methergine Increased methylergonovine exposure Details Dienogest Minocycline Amzeeq Decreased contraceptive efficacy Details Dienogest Minocycline Topical Amzeeq Decreased contraceptive efficacy Details Dienogest Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Dienogest Nafcillin Injection Unipen® Injection Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Dienogest Nevirapine Viramune Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Dienogest Nifedipine Adalat® Increased NIFEdipine exposure Details Dienogest Octreotide Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Dienogest Octreotide Injection Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Dienogest Penicillin G Procaine Injection Bactracillin G Decreased contraceptive effectiveness Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.