Digoxin and Amphotericin B Cholesteryl Sulfate Complex: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Digoxin
Amphotericin B Cholesteryl Sulfate Complex
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Hypokalemia and digitalis toxicity (nausea, vomiting, visual disturbances, cardiac arrhythmias)
Interaction Deep Dive
Concomitant digitalis glycosides and amphotericin B therapy may result in an increased risk of digitalis toxicity due to amphotericin B-induced potassium depletion1. A similar effect may occur with amphotericin B cholesteryl sulfate complex. Caution is warranted if these agents are to be given concomitantly.
Why it happens (mechanism)
Decreased serum potassium
Common questions
Can I take Digoxin and Amphotericin B Cholesteryl Sulfate Complex together?
Hypokalemia and digitalis toxicity (nausea, vomiting, visual disturbances, cardiac arrhythmias) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Digoxin and Amphotericin B Cholesteryl Sulfate Complex interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Digoxin or Amphotericin B Cholesteryl Sulfate Complex need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: Amphotec(R), amphotericin B cholesteryl sulfate complex. Sequus Pharmaceuticals, Inc. Menlo Park, CA, 1997. DailyMed
Keep reading about Digoxin
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