Digoxin and Elagolix: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Elagolix
Digoxin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased digoxin exposure
Interaction Deep Dive
Coadministration of elagolix (a P-gp inhibitor) with digoxin2 (a P-gp substrate 1) increased digoxin exposure. If initiating elagolix/estradiol/norethindrone with elagolix in a patient using digoxin, increase monitoring of digoxin concentrations and potential signs and symptoms of clinical toxicity. If elagolix/estradiol/norethindrone with elagolix is discontinued, increase monitoring of digoxin concentrations 2.
Why it happens (mechanism)
Inhibition of P-gp-mediated efflux transport of digoxin
Literature reports
1 report — tap to read
a) In a drug interaction study (n=11), administration of a single dose of digoxin 0.5 mg to subjects who took elagolix 200 mg twice daily for 10 days significantly increased the digoxin Cmax 1.7-fold (90% CI, 1.53 to 1.91) and the digoxin AUC 1.26-fold (90% CI, 1.17 to 1.35) 2.
Common questions
Can I take Digoxin and Elagolix together?
Increased digoxin exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Digoxin and Elagolix interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Digoxin or Elagolix need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: LANOXIN(R) oral tablets, digoxin oral tablets. Concordia Pharmaceuticals Inc (per FDA), Kansas City, MO, 2019. DailyMed
- Product Information: ORIAHNN(TM) oral capsules, elagolix, estradiol, norethindrone acetate oral capsules; elagolix oral capsules. AbbVie Inc (per manufacturer), North Chicago, IL, 2020. DailyMed
Keep reading about Elagolix
Keep reading about Digoxin
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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