Drug Interaction Report

Digoxin and Pheasant's Eye: Interaction Details

A pharmacist-reviewed analysis of the Digoxin and Pheasant's Eye interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Digoxin

Cardoxin® Digitek Digitek® Digox Lanoxicaps® Lanoxin Lanoxin®
+

Pheasant's Eye

No brand names on record
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 453 documented Digoxin interactions, 359 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
rapid
Evidence
theoretical
Severity
Major

What happens

Increased risk of digoxin toxicity

Interaction Deep Dive

Theoretically, an interaction could occur with pheasant's eye, since it contains cardiac glycosides similar in structure and function to digoxin. Both pheasant's eye and digitalis, the source of digoxin, are known to contain cardiac glycosides also known as cardenolides123. Pheasant's eye contains cymarin as its principal cardiac glycoside 4. At this time, pheasant's eye is not widely available in the United States 4.

Why it happens (mechanism)

Additive cardiac glycoside activity

Common questions

Can I take Digoxin and Pheasant's Eye together?

Increased risk of digoxin toxicity Always confirm with your pharmacist or prescriber before making any change.

How serious is the Digoxin and Pheasant's Eye interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Digoxin or Pheasant's Eye need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (4)

  1. Mashour NH, Lin GI, & Frishman WH: Herbal medicine for the treatment of cardiovascular disease. Arch Intern Med 1998; 158:2225-2234. DOI
  2. Loew D: Phytotherapy in heart failure. Phytomed 1997; 4:267-271. PubMed
  3. Krenn L, Schlifelner, Stimpfl T, et al: HPLC separation and quantitative determination of cardenolides in herba convallariae. Planta Med 1992; 58(Suppl 1):A682-684. DOI
  4. Blumenthal M, Busse WR, Goldberg A, et alBlumenthal M, Busse WR, Goldberg A, et al (Eds): The complete German commission E monographs, 1st. American Botanical Council, Austin, TX, 1998.
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Digoxin

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Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Digoxin + Activated Charcoal Aloe Blue Flag Danshen European Buckthorn Foxglove Indian Snakeroot Lily-of-the-valley + 105 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.