Digoxin and Vibegron: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Vibegron
Digoxin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased digoxin exposure
Interaction Deep Dive
Concomitant administration of vibegron and digoxin may increase digoxin exposure. In a drug interaction study concomitant administration of vibegron and digoxin increased digoxin Cmax by 21% and AUC by 11%. Monitor digoxin exposure before initiating and during therapy with vibegron and used for titration of the digoxin dose to obtain the desired clinical effect. Continue monitoring digoxin exposure upon discontinuation of vibegron and adjust digoxin dose as needed3. Also, monitor for potential signs and symptoms of clinical toxicity when initiating, adjusting, or discontinuing vibegron (P-gp inhibitor) 12.
Why it happens (mechanism)
Inhibition of P-gp mediated efflux transport of digoxin
Literature reports
1 report — tap to read
a) Concomitant administration of vibegron and digoxin increased digoxin Cmax by 21% and AUC by 11% in a drug interaction study 3.
Common questions
Can I take Digoxin and Vibegron together?
Increased digoxin exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Digoxin and Vibegron interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Digoxin or Vibegron need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Product Information: DIGOXIN oral tablets, digoxin oral tablets. Aurobindo Pharma USA, Inc. (per Dailymed), East Windsor, NJ, May. DailyMed
- Product Information: DIGOXIN intravenous injection, digoxin intravenous injection. Hikma Pharmaceuticals USA Inc. (per Dailymed), Berkeley Heights, NJ, 2023. DailyMed
- Product Information: GEMTESA(R) oral tablets, vibegron oral tablets. Urovant Sciences Inc (per FDA), Irvine, CA, 2020. DailyMed
Keep reading about Vibegron
Keep reading about Digoxin
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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