Digoxin

453 interactions 2 explained in plain English 980 cited references
Also sold as: Cardoxin® Digitek Digitek® Digox Lanoxicaps® Lanoxin Lanoxin®
About Digoxin

Digoxin is a cardiac glycoside used to treat heart failure and abnormal heart rhythms by strengthening the heart's contractions and slowing heart rate. Read the full Digoxin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Digoxin Midostaurin Rydapt Increased digoxin exposure Details Digoxin Mifepristone Korlym Increased digoxin exposure Details Digoxin Miglitol Glyset® Reduced digoxin exposure Details Digoxin Milk Thistle Increased digoxin exposure Details Digoxin Milnacipran Savella Potentiation of adverse hemodynamic effects Details Digoxin Minocycline Amzeeq Increased digoxin levels and digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Digoxin Mirabegron Myrbetriq Increased digoxin exposure Details Digoxin Moexipril Univasc® An increased digoxin exposure Details Digoxin Moricizine An increased risk of cardiotoxicity (first degree atrioventricular block, bundle branch block) Details Digoxin Morniflumate Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Nabumetone Relafen Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Naproxen Aleve Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Nefazodone Increased digoxin exposure Details Digoxin Nelfinavir Viracept Increased digoxin exposure Details Digoxin Neomycin Reduced digoxin exposure Details Digoxin Nepafenac Ilevro Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Neratinib Nerlynx Increased exposure to P-gp substrate and risk of toxicity Details Digoxin Nicardipine Cardene An increased risk of bradycardia and an increased risk of complete heart block Details Digoxin Nifedipine Adalat® Increased digoxin exposure and an increased risk of bradycardia and advanced complete heart block Details Digoxin Niflumic Acid Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Nilvadipine Increased risk of complete heart block Details Digoxin Nimesulide Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Nimesulide Beta Cyclodextrin Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Nimodipine Nimotop An increased risk of bradycardia and an increased risk of complete heart block Details Digoxin Nirmatrelvir Increased digoxin exposure, an increased risk of digoxin toxicity, and an increased risk of PR interval Details Digoxin Nisoldipine Sular An increased risk of bradycardia and an increased risk of complete heart block Details Digoxin Nitrendipine An increased risk of bradycardia and an increased risk of complete heart block Details Digoxin Norepinephrine An increased risk of cardiac arrhythmias Details Digoxin Octreotide Bynfezia Decreased digoxin exposure Details Digoxin Oleander Increased risk of digoxin toxicity Details Digoxin Olmesartan Benicar An increased digoxin exposure Details Digoxin Osimertinib Tagrisso Increased digoxin exposure Details Digoxin Oxaprozin Coxanto Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Oxyphenbutazone Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Oxytetracycline Increased digoxin levels and digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Digoxin Pacritinib Vonjo® Increased digoxin exposure and an increased risk of digoxin-related adverse reactions Details Digoxin Pantoprazole Protonix An increased risk of serious adverse reactions Details Digoxin Parathyroid Hormone Increased risk of digoxin toxicity and reduced digoxin exposure Details Digoxin Parecoxib Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Paroxetine Paxil Altered digoxin exposure and reduced efficacy of digoxin Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.