Drug Interaction Report

Digoxin and Miglitol: Interaction Details

A pharmacist-reviewed analysis of the Digoxin and Miglitol interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Miglitol

Glyset®
+

Digoxin

Cardoxin® Digitek Digitek® Digox Lanoxicaps® Lanoxin Lanoxin®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 453 documented Digoxin interactions, 359 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
delayed
Evidence
probable
Severity
Major

What happens

Reduced digoxin exposure

Interaction Deep Dive

Coadministration of digoxin and miglitol may reduce digoxin exposure. The average digoxin plasma concentration was reduced by 19% and 28%, respectively, after coadministration of oral miglitol 50 mg or 100 mg 3 times daily in healthy volunteers. However, no alteration in the digoxin plasma concentration was reported in patients with diabetes who were already receiving digoxin after 14 days of concomitant therapy with miglitol 100 mg orally 3 times daily1. Measure digoxin exposure prior to initiation of concurrent use. Increase the digoxin dose by approximately 20% to 40%, if necessary, and continue monitoring digoxin exposure 23.

Why it happens (mechanism)

Unknown

Literature reports

1 report — tap to read

a) The average digoxin plasma concentration was reduced by 19% and 28%, respectively, after coadministration of oral miglitol 50 mg or 100 mg 3 times daily in healthy volunteers. However, no alteration in the digoxin plasma concentration was reported in patients with diabetes who were already receiving digoxin after 14 days of concomitant therapy with miglitol 100 mg orally 3 times daily 1.

Common questions

Can I take Digoxin and Miglitol together?

Reduced digoxin exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Digoxin and Miglitol interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "delayed". Effects tend to build up gradually over days to weeks.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

Questions for your pharmacist

  • Does my dose of Digoxin or Miglitol need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (3)

  1. Product Information: GLYSET(R) oral film coated tablet, miglitol oral film coated tablet. Pharmacia & Upjohn Co. New York, NY, 2010. DailyMed
  2. Product Information: LANOXIN(R) oral tablets, digoxin oral tablets. Concordia Pharmaceuticals Inc (per FDA), Kansas City, MO, 2019. DailyMed
  3. Product Information: DIGOXIN oral tablets, digoxin oral tablets. Aurobindo Pharma USA, Inc. (per Dailymed), East Windsor, NJ, May. DailyMed
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Miglitol

Keep reading about Miglitol

All Miglitol interactions (107) Miglitol drug information
Also serious with: Hydroflumethiazide Indapamide Hydrochlorothiazide Grepafloxacin
Digoxin

Keep reading about Digoxin

All Digoxin interactions (453) Digoxin drug information
Also serious with: Levoketoconazole Meclofenamate Mavorixafor Parathyroid Hormone Injection
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Miglitol + Activated Charcoal Siberian Cocklebur Acai African Wild Potato Agaricus Mushroom Agmatine Agrimony Alfalfa + 248 more
Digoxin + Activated Charcoal Aloe Blue Flag Danshen European Buckthorn Foxglove Indian Snakeroot Lily-of-the-valley + 105 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.