Digoxin

453 interactions 2 explained in plain English 980 cited references
Also sold as: Cardoxin® Digitek Digitek® Digox Lanoxicaps® Lanoxin Lanoxin®
About Digoxin

Digoxin is a cardiac glycoside used to treat heart failure and abnormal heart rhythms by strengthening the heart's contractions and slowing heart rate. Read the full Digoxin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Digoxin Schizandra Increased digoxin exposure Details Digoxin Selpercatinib Retevmo Increased digoxin exposure and an increased risk of digoxin-related adverse effects Details Digoxin Simeprevir Olysio® Increased digoxin exposure and an increased risk of digoxin toxicity Details Digoxin Siponimod Mayzent An increased risk of severe bradycardia and heart block Details Digoxin Sodium Bicarbonate Alka-Seltzer® Heartburn Reduced digoxin exposure Details Digoxin Sodium Salicylate Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Sotagliflozin Inpefa Increased digoxin exposure Details Digoxin Sotalol Betapace Increased risk of bradycardia, advanced or complete heart block and an increased risk of proarrhythmic events Details Digoxin Sotorasib Lumakras Increased exposure to P-gp substrate and risk of toxicity Details Digoxin Spirapril An increased digoxin exposure Details Digoxin Spironolactone Aldactone Increased digoxin exposure Details Digoxin Squill Increased risk of digoxin toxicity Details Digoxin St John's Wort Altered digoxin exposure and an increased risk of digoxin toxicity Details Digoxin Succinylcholine Anectine An increased risk of cardiac arrhythmias Details Digoxin Sucralfate Carafate Reduced digoxin exposure Details Digoxin Sulfasalazine Azulfidine Reduced digoxin exposure Details Digoxin Sulindac Clinoril® Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Sunvozertinib Zegfrovy Increased P-gp substrates with NTI exposure and increased risk of P-gp substrates with NTI-related adverse effects Details Digoxin Suvorexant Belsomra Increased digoxin exposure and an increased risk of digoxin-related adverse reaction Details Digoxin Taletrectinib Ibtrozi Increased risk of QT interval prolongation and torsade de pointes Details Digoxin Taurursodiol Increased exposure of the P-gp substrate Details Digoxin Telaprevir Increased digoxin exposure Details Digoxin Telithromycin Increased digoxin exposure Details Digoxin Telmisartan Micardis An increased digoxin exposure Details Digoxin Tenoxicam Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Tepotinib Tepmetko Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse effects Details Digoxin Teriparatide Increased risk of digoxin toxicity Details Digoxin Tetracycline Achromycin V® Increased digoxin exposure Details Digoxin Tezacaftor Increased exposure to P-gp substrates and increased risk of P-gp substrates-related adverse effects Details Digoxin Tiaprofenic Acid Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Ticagrelor Brilinta Increased digoxin exposure Details Digoxin Tipranavir Aptivus Reduced digoxin exposure Details Digoxin Tolfenamic Acid Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Tolmetin Tolectin 600 Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Tolvaptan Jynarque Increased digoxin exposure Details Digoxin Tramadol ConZip Increased risk of digoxin toxicity Details Digoxin Trandolapril Mavik® An increased digoxin exposure Details Digoxin Trazodone Raldesy Increased digoxin exposure and an increased risk of digoxin toxicity (nausea, vomiting, arrhythmias) Details Digoxin Trichlormethiazide Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Digoxin Trimethoprim Primsol An increased digoxin exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.