Dipyridamole and Fluvoxamine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Fluvoxamine
No brand names on recordDipyridamole
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of bleeding
Interaction Deep Dive
Exercise caution when coadministering a SSRI and an antiplatelet agent as this may increase the risk of bleeding events12.3. Bleeding events reported have included epistaxis, ecchymosis, hematoma, petechiae, and life-threatening hemorrhages. Monitor patient for signs of increased bleeding when fluvoxaMINE is administered with an antiplatelet agent concomitantly 3.
Why it happens (mechanism)
Release of serotonin by platelets; additive effects on hemostasis
Literature reports
2 reports — tap to read
a) In a retrospective study of patients over 50 years of age with the diagnosis of acute myocardial infarction (N=27,058), SSRI use with any antiplatelet therapy significantly increased the risk of bleeding by 1.42-fold compared with aspirin use alone. Therapy with aspirin, clopidogrel, and an SSRI significantly increased risk by 2.35-fold compared with aspirin use alone and by 1.57-fold compared with clopidogrel and aspirin combination therapy 2.
b) In a systematic review and meta-analysis of 22 observational studies, SSRI use was associated with a significant 1.55 fold increase in risk of upper gastrointestinal bleeding (UGIB). Concomitant use of SSRIs and antiplatelet drugs was associated with a 2.48-fold increase in risk of UGIB (3 studies) 1.
Common questions
Can I take Dipyridamole and Fluvoxamine together?
An increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dipyridamole and Fluvoxamine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Dipyridamole or Fluvoxamine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Jiang HY, Chen HZ, Hu XJ, et al: Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal bleeding: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2015; 13(1):42-50. PubMed
- Labos C, Dasgupta K, Nedjar H, et al: Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction. CMAJ 2011; 183(16):1835-1843. PubMed
- Product Information: Fluvoxamine maleate oral tablets, fluvoxamine maleate oral tablets. ANI Pharmaceuticals Inc (per FDA), Baudette, MN, 2023. DailyMed
Keep reading about Fluvoxamine
Keep reading about Dipyridamole
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