Disopyramide

284 interactions 642 cited references

Also sold as: Norpace Norpace® Norpace® CR

About Disopyramide

Disopyramide is used to treat certain types of irregular heartbeats). Disopyramide is in a class of medications called antiarrhythmic medications. It works by making your heart more resistant to abnormal activity. Read the full Disopyramide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levomethadyl Levoketoconazole Mesoridazine Itraconazole Pimozide Piperaquine

15 Contraindicated 247 Major 22 Moderate

All (284) Contraindicated (15) Major (247) Moderate (22)

Major

Disopyramide Pitolisant Wakix Increased risk of QT interval prolongation Details Disopyramide Ponesimod Ponvory Increased risk of bradycardia, an increased risk of QT prolongation and torsades de pointes Details Disopyramide Posaconazole Noxafil An increased risk of QT interval prolongation Details Disopyramide Prilocaine An increased risk of cardiotoxicity Details Disopyramide Primidone Mysoline An increased risk of QT interval prolongation, reduced disopyramide exposure and reduced disopyramide efficacy Details Disopyramide Probucol An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Procainamide Procan® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Prochlorperazine An increased risk of QT interval prolongation Details Disopyramide Promethazine Phenadoz An increased risk of QT interval prolongation Details Disopyramide Propafenone Rythmol An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Protriptyline An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Quetiapine Seroquel An increased risk of QT interval prolongation Details Disopyramide Quinidine Cardioquin® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Quinine An increased risk of QT interval prolongation Details Disopyramide Quizartinib Vanflyta An increased risk of QT interval prolongation Details Disopyramide Ranolazine Aspruzyo An increased risk of QT interval prolongation Details Disopyramide Revumenib Revuforj An increased risk of QT interval prolongation Details Disopyramide Ribociclib Kisqali An increased risk of QT interval prolongation Details Disopyramide Rifampin Rifadin Reduced disopyramide exposure Details Disopyramide Rilpivirine Edurant An increased risk of QT interval prolongation and torsade de pointes Details Disopyramide Risperidone Perseris An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Ritonavir Norvir Increased disopyramide exposure and potential toxicity (anticholinergic effects, hypotension, heart failure, cardiac arrhythmias) Details Disopyramide Selpercatinib Retevmo Increased risk of QT interval prolongation Details Disopyramide Sertindole An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Sevoflurane Petrem Increased risk of QT interval prolongation Details Disopyramide Simeprevir Olysio® Increased exposure to the antiarrhythmic agent Details Disopyramide Siponimod Mayzent An increased risk of QT interval prolongation Details Disopyramide Sodium Phosphate OsmoPrep An increased risk of QT interval prolongation Details Disopyramide Sodium Phosphate, Dibasic An increased risk of QT interval prolongation Details Disopyramide Sodium Phosphate, Monobasic An increased risk of QT interval prolongation Details Disopyramide Solifenacin Vesicare An increased risk of QT interval prolongation Details Disopyramide Sorafenib Nexavar An increased risk of QT interval prolongation Details Disopyramide Sotalol Betapace Increased risk of QT interval prolongation or prolonged refractoriness Details Disopyramide Spiramycin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Sulfamethoxazole Sustain An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Sulpiride An increased risk of QT interval prolongation Details Disopyramide Sultopride An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Disopyramide Sunitinib Sutent An increased risk of QT interval prolongation Details Disopyramide Tacrolimus Astagraf An increased risk of QT interval prolongation Details Disopyramide Taletrectinib Ibtrozi Increased risk of QT interval prolongation and torsade de pointes Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.