Disopyramide and Sotalol: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Disopyramide
Sotalol
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of QT interval prolongation or prolonged refractoriness
Interaction Deep Dive
Avoid concomitant use of sotalol with Class I or Class III antiarrhythmic drugs. Discontinue use of Class I or Class III antiarrhythmic drugs for at least 3 half-lives prior to dosing sotalol1. Isolated cases of QTc prolongation and torsade de pointes have been reported with sotalol 2.
Why it happens (mechanism)
Additive effects on refractory potential
Common questions
Can I take Disopyramide and Sotalol together?
Increased risk of QT interval prolongation or prolonged refractoriness Always confirm with your pharmacist or prescriber before making any change.
How serious is the Disopyramide and Sotalol interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Disopyramide or Sotalol need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: BETAPACE(R) AF oral tablets, sotalol HCl oral tablets. Covis Pharma (per FDA), King of Prussia, PA, 2023. DailyMed
- Marill KA & Runge T: Meta-analysis of the risk of torsades de pointes in patients treated with intravenous racemic sotalol. Acad Emerg Med 2001; 8(2):117-124. PubMed
Keep reading about Disopyramide
Keep reading about Sotalol
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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