Drug Interaction Report

Dobutamine and Nebivolol: Interaction Details

A pharmacist-reviewed analysis of the Dobutamine and Nebivolol interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Nebivolol

Bystolic Bystolic®
+

Dobutamine

No brand names on record
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 14 documented Dobutamine interactions, 5 are rated moderate — including this one.
Onset
unspecified
Evidence
theoretical
Severity
Moderate

What happens

Reversal of the beta-blocking effects of nebivolol and, potentially, severe hypotension

Interaction Deep Dive

DOBUTamine stimulates the cardiac beta receptors, resulting in mild chronotropic, hypertensive, and vasodilatory effects2. Nebivolol is a preferentially beta-1 selective blocker. With concurrent administration, although the beta-blocking effects of nebivolol can be reversed by the beta-1 agonistic activity of DOBUTamine, vasodilation due to the beta-2 agonistic effects of DOBUTamine may result in protracted severe hypotension 1. Caution and close monitoring of blood pressure are recommended if these agents are used concurrently.

Why it happens (mechanism)

Pharmacological antagonism; vasodilatory effects of DOBUTamine

Common questions

Can I take Dobutamine and Nebivolol together?

Reversal of the beta-blocking effects of nebivolol and, potentially, severe hypotension Always confirm with your pharmacist or prescriber before making any change.

How serious is the Dobutamine and Nebivolol interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Dobutamine or Nebivolol need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (2)

  1. Product Information: BYSTOLIC(TM) oral tablets, nebivolol oral tablets. Forest Laboratories,Inc, St.Louis, MO, 2007. DailyMed
  2. Product Information: dobutamine injection, dobutamine injection. Bedford Laboratories, Bedford, OH, 2005. DailyMed
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Nebivolol

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Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Nebivolol + Activated Charcoal American Hellebore American Mistletoe Indian Snakeroot Tyramine 1,3-dmaa Acacia Rigidula Active Hexose Correlated Compound (ahcc) + 175 more
Dobutamine + Activated Charcoal Coffee Charcoal European Mandrake Glucomannan Guar Gum Gum Arabic Slippery Elm Tragacanth + 9 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.