Doxycycline Injection

118 interactions 541 cited references

Also sold as: Acticlate Adoxa Alodox Avidoxy Doryx Doxy Doxy 100® Doxy 200® Mondoxyne Monodox Morgidox Okebo Oracea Periostat Targadox Vibramycin

About Doxycycline Injection

Doxycycline injection is used to treat or prevent bacterial infections, including pneumonia and other respiratory tract infections. It is also used to treat certain skin, genital, intestine, and urinary system infections. Doxycycline injection may be used to treat or prevent anthrax (a serious infection that may be spr… Read the full Doxycycline Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acitretin Acenocoumarol Amobarbital Amoxicillin Ampicillin Apixaban

1 Contraindicated 88 Major 29 Moderate

All (118) Contraindicated (1) Major (88) Moderate (29)

Contraindicated

Doxycycline Injection Acitretin Soriatane® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

Major

Doxycycline Injection Acenocoumarol An increased risk of bleeding Details Doxycycline Injection Amobarbital Amytal Reduced doxycycline exposure and reduced efficacy of doxycycline Details Doxycycline Injection Amoxicillin Amoxi Drop Decreased antibacterial effectiveness Details Doxycycline Injection Ampicillin Amcill® Decreased antibacterial effectiveness Details Doxycycline Injection Apixaban Eliquis An increased risk of bleeding Details Doxycycline Injection Aprobarbital Reduced doxycycline exposure and reduced efficacy of doxycycline Details Doxycycline Injection Ardeparin An increased risk of bleeding Details Doxycycline Injection Argatroban An increased risk of bleeding Details Doxycycline Injection Ascorbic Acid Decreased doxycycline efficacy Details Doxycycline Injection Bacampicillin Decreased antibacterial effectiveness Details Doxycycline Injection Barbital Reduced doxycycline exposure and reduced efficacy of doxycycline Details Doxycycline Injection Bemiparin An increased risk of bleeding Details Doxycycline Injection Betrixaban Bevyxxa® An increased risk of bleeding Details Doxycycline Injection Bexarotene Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Doxycycline Injection Bivalirudin Angiomax An increased risk of bleeding Details Doxycycline Injection Butabarbital Reduced doxycycline exposure and reduced efficacy of doxycycline Details Doxycycline Injection Butalbital Reduced doxycycline exposure and reduced efficacy of doxycycline Details Doxycycline Injection Certoparin An increased risk of bleeding Details Doxycycline Injection Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Doxycycline Injection Cloxacillin Decreased antibacterial effectiveness Details Doxycycline Injection Dabigatran Etexilate An increased risk of bleeding Details Doxycycline Injection Dalteparin Fragmin An increased risk of bleeding Details Doxycycline Injection Danaparoid An increased risk of bleeding Details Doxycycline Injection Desirudin Iprivask An increased risk of bleeding Details Doxycycline Injection Desogestrel Reduced efficacy of oral contraceptive Details Doxycycline Injection Dicloxacillin Decreased antibacterial effectiveness Details Doxycycline Injection Dienogest Reduced efficacy of oral contraceptive Details Doxycycline Injection Drospirenone Reduced efficacy of oral contraceptive Details Doxycycline Injection Edoxaban Savaysa An increased risk of bleeding Details Doxycycline Injection Enoxaparin Lovenox An increased risk of bleeding Details Doxycycline Injection Estetrol Reduced efficacy of oral contraceptive Details Doxycycline Injection Estradiol Delestrogen Reduced efficacy of oral contraceptive Details Doxycycline Injection Eterobarb Reduced doxycycline exposure and reduced efficacy of doxycycline Details Doxycycline Injection Ethinyl Estradiol Reduced efficacy of oral contraceptive Details Doxycycline Injection Ethynodiol Reduced efficacy of oral contraceptive Details Doxycycline Injection Etretinate An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Doxycycline Injection Exenatide Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Doxycycline Injection Fondaparinux Arixtra An increased risk of bleeding Details Doxycycline Injection Fosphenytoin Cerebyx Reduced doxycycline exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.