Drug Interaction Report

Edoxaban and Quinidine: Interaction Details

A pharmacist-reviewed analysis of the Edoxaban and Quinidine interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Edoxaban

Savaysa Savaysa®
+

Quinidine

Cardioquin® Cin-Quin® Duraquin® Quinact® Quinaglute® Quinalan® Quinatime® Quinidex®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 244 documented Edoxaban interactions, 215 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Increased edoxaban exposure

Interaction Deep Dive

Concomitant use of edoxaban (a P-gp substrate) and certain P-gp inhibitors (ie, verapamil, quiNIDine, azithromycin, clarithromycin, erythromycin, oral itraconazole, or oral ketoconazole) may increase edoxaban exposure in patients being treated with edoxaban for DVT or pulmonary embolism. No dosage adjustments are needed for concomitant use with these P-gp inhibitors in patients receiving edoxaban for nonvalvular atrial fibrillation; however, if treated for DVT or pulmonary embolism, the edoxaban dosage should be reduced to 30 mg orally once daily1. Additionally, edoxaban dosage reduction to 30 mg once daily is suggested if coadministered with dronedarone or cycloSPORINE (P-gp inhibitors). If coadministration with amiodarone (P-gp inhibitor) is required, administer cautiously with close monitoring 2.

Why it happens (mechanism)

Inhibition of P-gp-mediated edoxaban transport

Literature reports

1 report — tap to read

a) Coadministration of P-gp inhibitors including amiodarone, dronedarone, quiNIDine, verapamil, and cycloSPORINE increased the AUC of edoxaban by 40%, 85%, 77%, 53%, and 73%, respectively 2.

Common questions

Can I take Edoxaban and Quinidine together?

Increased edoxaban exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Edoxaban and Quinidine interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Edoxaban or Quinidine need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (2)

  1. Product Information: SAVAYSA(R) oral tablets, edoxaban oral tablets. Daiichi Sankyo Inc (per FDA), Basking Ridge, NJ, 2023. DailyMed
  2. Steffel J, Collins R, Antz M, et al: 2021 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. Europace 2021; 23(10):1612-1676.
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Edoxaban

Keep reading about Edoxaban

All Edoxaban interactions (244) Edoxaban drug information
Also serious with: Defibrotide Defibrotide Injection Piketoprofen Oxaliplatin Injection
Quinidine

Keep reading about Quinidine

All Quinidine interactions (91) Quinidine drug information
Also serious with: Colchicine Ketoconazole Topical Lefamulin Dofetilide
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Edoxaban + Activated Charcoal Danshen Piracetam Aconite Allspice Aloe Alpha-lipoic Acid Andrographis + 210 more
Quinidine + Activated Charcoal American Hellebore Arsenic Beer Cesium Cinchona Ephedra Grapefruit + 199 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.