Eletriptan and Dihydroergotamine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Eletriptan
Dihydroergotamine Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of prolonged vasospastic reactions
Interaction Deep Dive
Both dihydroergotamine and eletriptan may cause vasospastic reactions. When used concomitantly, these effects may be additive. The use of dihydroergotamine and eletriptan within 24 hours of each other is contraindicated12.
Why it happens (mechanism)
Additive vasospastic response
Common questions
Can I take Eletriptan and Dihydroergotamine Injection together?
Increased risk of prolonged vasospastic reactions Always confirm with your pharmacist or prescriber before making any change.
How serious is the Eletriptan and Dihydroergotamine Injection interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Eletriptan or Dihydroergotamine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: RELPAX(R) oral tablets, eletriptan hydrobromide oral tablets. Roerig (per DailyMed), New York, NY, 2012. DailyMed
- Product Information: dihydroergotamine mesylate intravenous injection, intramuscular injection, subcutaneous injection, dihydroergotamine mesylate intravenous injection, intramuscular injection, subcutaneous injection. Bedford Laboratories (per DailyMed), Bedford, OH, 2008. DailyMed
Keep reading about Eletriptan
Keep reading about Dihydroergotamine Injection
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