Erlotinib

83 interactions 141 cited references

Also sold as: Tarceva Tarceva®

About Erlotinib

Erlotinib is used to treat certain types of non-small cell lung cancer that has spread to nearby tissues or to other parts of the body in patients who have already been treated with at least one other chemotherapy medication and have not gotten better. Erlotinib is also used in combination with another medication (gemc… Read the full Erlotinib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bacillus Of Calmette And Guerin Vaccine, Live Dengue Tetravalent Vaccine, Live Smallpox Monkeypox Vaccine Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live

9 Contraindicated 58 Major 16 Moderate

All (83) Contraindicated (9) Major (58) Moderate (16)

Contraindicated

Erlotinib Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Erlotinib Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Erlotinib Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Erlotinib Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Erlotinib Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Erlotinib Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Erlotinib Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Erlotinib Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Erlotinib Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Erlotinib Omeprazole Gastrobim Reduced erlotinib exposure Details Erlotinib Azathioprine Azasan An increased risk of hepatotoxicity Details Erlotinib Dexlansoprazole Dexilant Reduced erlotinib exposure Details Erlotinib Acenocoumarol An increased risk of bleeding Details Erlotinib Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Erlotinib Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Erlotinib Amiodarone Nexterone Neurotoxicity Details Erlotinib Boceprevir Increased erlotinib exposure and risk of toxicity Details Erlotinib Carbamazepine Carbatrol Decreased erlotinib exposure and potential loss of efficacy Details Erlotinib Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Erlotinib Cimetidine Tagamet Reduced erlotinib exposure Details Erlotinib Ciprofloxacin Increased erlotinib exposure and risk of toxicity Details Erlotinib Clarithromycin Biaxin Increased erlotinib exposure and risk of toxicity Details Erlotinib Cobicistat Tybost Increased erlotinib exposure and risk of toxicity Details Erlotinib Conivaptan Vaprisol Increased erlotinib exposure and risk of toxicity Details Erlotinib Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Erlotinib Enzalutamide Xtandi Decreased erlotinib exposure and potential loss of efficacy Details Erlotinib Esomeprazole Nexium Reduced erlotinib exposure Details Erlotinib Famotidine Calmicid Reduced erlotinib exposure Details Erlotinib Fosphenytoin Cerebyx Decreased erlotinib exposure and potential loss of efficacy Details Erlotinib Idelalisib Zydelig Increased erlotinib exposure and risk of toxicity Details Erlotinib Indinavir Increased erlotinib exposure and risk of toxicity Details Erlotinib Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Erlotinib Itraconazole Sporanox Increased erlotinib exposure and risk of toxicity Details Erlotinib Ketoconazole Extina Increased erlotinib exposure and risk of toxicity Details Erlotinib Lansoprazole Prevacid Reduced erlotinib exposure Details Erlotinib Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Erlotinib Lopinavir Increased erlotinib exposure and risk of toxicity Details Erlotinib Lumacaftor Decreased erlotinib exposure and potential loss of efficacy Details Erlotinib Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Erlotinib Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.