Esketamine Nasal Spray

194 interactions 98 cited references

Also sold as: Spravato Spravato®

About Esketamine Nasal Spray

Esketamine nasal spray is used along with another antidepressant, taken by mouth, to manage treatment-resistant depression (TRD; depression that does not improve with treatment) in adults. It is also used along with another antidepressant, taken by mouth, to treat depressive symptoms in adults with major depressive dis… Read the full Esketamine Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isocarboxazid Zuranolone Fospropofol Foslevodopa Foscarbidopa Fluspirilene

1 Contraindicated 183 Major 10 Moderate

All (194) Contraindicated (1) Major (183) Moderate (10)

Major

Esketamine Nasal Spray Dichloralphenazone Increased risk of sedation Details Esketamine Nasal Spray Difenoxin Increased risk of sedation Details Esketamine Nasal Spray Dihydrocodeine Increased risk of sedation Details Esketamine Nasal Spray Diphenhydramine Banophen Increased risk of sedation Details Esketamine Nasal Spray Diphenoxylate Increased risk of sedation Details Esketamine Nasal Spray Doxepin Prudoxin An increased risk of CNS depression Details Esketamine Nasal Spray Doxylamine Aldex AN Increased risk of sedation Details Esketamine Nasal Spray Droperidol Increased risk of sedation Details Esketamine Nasal Spray Enflurane Increased risk of sedation Details Esketamine Nasal Spray Estazolam Increased risk of sedation Details Esketamine Nasal Spray Eszopiclone Lunesta Increased risk of sedation Details Esketamine Nasal Spray Ethchlorvynol Increased risk of sedation Details Esketamine Nasal Spray Ethopropazine Increased risk of sedation Details Esketamine Nasal Spray Ethylmorphine Increased risk of sedation Details Esketamine Nasal Spray Fentanyl Increased risk of sedation Details Esketamine Nasal Spray Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Esketamine Nasal Spray Flibanserin Addyi Increased risk of sedation Details Esketamine Nasal Spray Fluphenazine Increased risk of sedation Details Esketamine Nasal Spray Flurazepam Increased risk of sedation Details Esketamine Nasal Spray Fluspirilene Increased risk of sedation Details Esketamine Nasal Spray Foscarbidopa An increased risk of CNS depression Details Esketamine Nasal Spray Foslevodopa An increased risk of CNS depression Details Esketamine Nasal Spray Fospropofol Increased risk of sedation Details Esketamine Nasal Spray Gabapentin Gabarone An increased risk of respiratory depression and sedation Details Esketamine Nasal Spray Gabapentin Enacarbil Horizant An increased risk of respiratory depression Details Esketamine Nasal Spray Halazepam Increased risk of sedation Details Esketamine Nasal Spray Haloperidol Increased haloperidol exposure, an increased risk of haloperidol-related adverse events and an increased risk of CNS depression Details Esketamine Nasal Spray Halothane Increased risk of sedation Details Esketamine Nasal Spray Hexobarbital Increased risk of sedation Details Esketamine Nasal Spray Hydrocodone Hysingla Increased risk of sedation Details Esketamine Nasal Spray Hydromorphone Dilaudid Increased risk of sedation Details Esketamine Nasal Spray Hydroxyzine Increased risk of sedation Details Esketamine Nasal Spray Isoflurane Fluriso Increased risk of sedation Details Esketamine Nasal Spray Ketamine Increased risk of respiratory and CNS depression Details Esketamine Nasal Spray Ketazolam Increased risk of sedation Details Esketamine Nasal Spray Ketobemidone Increased risk of sedation Details Esketamine Nasal Spray Kratom An increased risk of CNS depression Details Esketamine Nasal Spray Lacosamide Motpoly An increased risk of CNS depression Details Esketamine Nasal Spray Lemborexant Dayvigo An increased risk of CNS depression and potential next-day somnolence, an increased lemborexant exposure, an increased risk of lem... Details Esketamine Nasal Spray Levocetirizine Xyzal Increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.