Esketamine Nasal Spray

Name: Esketamine Nasal Spray Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

194 interactions 98 cited references

Also sold as: Spravato Spravato®

About Esketamine Nasal Spray

Esketamine nasal spray is used along with another antidepressant, taken by mouth, to manage treatment-resistant depression (TRD; depression that does not improve with treatment) in adults. It is also used along with another antidepressant, taken by mouth, to treat depressive symptoms in adults with major depressive dis… Read the full Esketamine Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isocarboxazid Zuranolone Fospropofol Foslevodopa Foscarbidopa Fluspirilene

1 Contraindicated 183 Major 10 Moderate

All (194) Contraindicated (1) Major (183) Moderate (10)

Contraindicated

Esketamine Nasal Spray Isocarboxazid Marplan An increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.