Esketamine Nasal Spray
194 interactions 98 cited referencesEsketamine nasal spray is used along with another antidepressant, taken by mouth, to manage treatment-resistant depression (TRD; depression that does not improve with treatment) in adults. It is also used along with another antidepressant, taken by mouth, to treat depressive symptoms in adults with major depressive dis… Read the full Esketamine Nasal Spray drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Moderate
Esketamine Nasal Spray Artemether Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Esketamine Nasal Spray Brimonidine Alphagan An increased risk of CNS depression Details Esketamine Nasal Spray Carbachol Isopto Carbachol An increased risk of CNS depression Details Esketamine Nasal Spray Clonidine Duraclon An increased risk of sedation and somnolence Details Esketamine Nasal Spray Dofetilide Tikosyn Increased dofetilide exposure Details Esketamine Nasal Spray Ganaxolone Ztalmy An increased risk of somnolence and sedation Details Esketamine Nasal Spray Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Esketamine Nasal Spray Lumefantrine Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Esketamine Nasal Spray Sparsentan Filspari Reduced CYP2B6 substrate exposure and reduced efficacy of CYP2B6 substrate Details Esketamine Nasal Spray Thiotepa Tepadina Increased CYP2B6 substrates exposure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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