Esketamine Nasal Spray

194 interactions 98 cited references
Also sold as: Spravato Spravato®
About Esketamine Nasal Spray

Esketamine nasal spray is used along with another antidepressant, taken by mouth, to manage treatment-resistant depression (TRD; depression that does not improve with treatment) in adults. It is also used along with another antidepressant, taken by mouth, to treat depressive symptoms in adults with major depressive dis… Read the full Esketamine Nasal Spray drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isocarboxazid Zuranolone Fospropofol Foslevodopa Foscarbidopa Fluspirilene
1 Contraindicated 183 Major 10 Moderate
All (194) Contraindicated (1) Major (183) Moderate (10)

Major

Esketamine Nasal Spray Acepromazine PROMACE Increased risk of sedation Details Esketamine Nasal Spray Alfentanil Increased ALfentanil exposure and an increased risk of respiratory or CNS depression and hypotension Details Esketamine Nasal Spray Alprazolam Xanax Increased risk of sedation Details Esketamine Nasal Spray Amobarbital Amytal Increased risk of sedation Details Esketamine Nasal Spray Anileridine Increased risk of sedation Details Esketamine Nasal Spray Aripiprazole Abilify Increased risk of sedation Details Esketamine Nasal Spray Asenapine Saphris Increased risk of sedation Details Esketamine Nasal Spray Baclofen Fleqsuvy Increased risk of sedation Details Esketamine Nasal Spray Benperidol Increased risk of sedation Details Esketamine Nasal Spray Benzhydrocodone Increased risk of sedation Details Esketamine Nasal Spray Bromazepam Increased risk of sedation Details Esketamine Nasal Spray Buprenorphine Belbuca An increased risk of respiratory depression and CNS depression Details Esketamine Nasal Spray Buspirone Bucapsol Increased risk of sedation Details Esketamine Nasal Spray Butalbital Increased risk of sedation Details Esketamine Nasal Spray Butorphanol Butorphic Increased risk of sedation Details Esketamine Nasal Spray Calcium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Esketamine Nasal Spray Cannabidiol Epidiolex Altered (increased or reduced) esketamine exposure, an increased risk of CNS depression and an increased risk of sedation and somn... Details Esketamine Nasal Spray Cannabis An increased risk of CNS depression Details Esketamine Nasal Spray Carbamazepine Carbatrol Reduced CYP2B6 substrate exposure and reduced efficacy of CYP2B6 substrate and an increased risk of respiratory depression, profou... Details Esketamine Nasal Spray Carbidopa Lodosyn An increased risk of CNS depression Details Esketamine Nasal Spray Carbinoxamine Carbzah Increased risk of sedation Details Esketamine Nasal Spray Carisoprodol Soma Increased risk of sedation Details Esketamine Nasal Spray Carphenazine Increased risk of sedation Details Esketamine Nasal Spray Cetirizine Aller-Tec Increased risk of CNS depression Details Esketamine Nasal Spray Chloral Hydrate Increased risk of sedation Details Esketamine Nasal Spray Chlordiazepoxide Increased risk of sedation Details Esketamine Nasal Spray Chlorpromazine Increased risk of sedation Details Esketamine Nasal Spray Chlorzoxazone Lorzone Increased risk of sedation Details Esketamine Nasal Spray Clobazam Onfi Increased risk of sedation Details Esketamine Nasal Spray Clomipramine Anafranil An increased risk of CNS depression Details Esketamine Nasal Spray Clonazepam Klonopin Increased risk of sedation Details Esketamine Nasal Spray Clorazepate Tranxene Increased risk of sedation Details Esketamine Nasal Spray Clozapine Clozaril Increased risk of sedation Details Esketamine Nasal Spray Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) Increased risk of sedation Details Esketamine Nasal Spray Cyclobenzaprine Amrix Increased risk of sedation Details Esketamine Nasal Spray Cyproheptadine An increased risk of CNS depression Details Esketamine Nasal Spray Daridorexant An increased risk CNS depression Details Esketamine Nasal Spray Dexmedetomidine Dexased Increased risk of sedation Details Esketamine Nasal Spray Diacetylmorphine Increased risk of sedation Details Esketamine Nasal Spray Diazepam Diastat Increased risk of sedation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.