Esomeprazole Injection

95 interactions 452 cited references

Also sold as: Nexium Nexium I.V.®

About Esomeprazole Injection

Esomeprazole injection is used to treat gastroesophageal reflux disease (GERD; a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus [the tube between the throat and stomach]) in adults and children 1 month of age or older who have had damage to their esophagu… Read the full Esomeprazole Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rilpivirine Acalabrutinib Alfentanil Amphetamine Apalutamide Atazanavir

1 Contraindicated 76 Major 17 Moderate 1 Minor

All (95) Contraindicated (1) Major (76) Moderate (17) Minor (1)

Contraindicated

Esomeprazole Injection Rilpivirine Edurant Reduced oral rilpivirine exposure, reduced efficacy of rilpivirine and an increased loss of virologic response Details

Major

Esomeprazole Injection Acalabrutinib Calquence Reduced acalabrutinib exposure Details Esomeprazole Injection Alfentanil Increased ALfentanil exposure and an increased risk of respiratory depression Details Esomeprazole Injection Amphetamine Dexedrine Increased exposure to amphetamine Details Esomeprazole Injection Apalutamide Erleada Reduced CYP2C19 substrate exposure Details Esomeprazole Injection Atazanavir Reyataz Reduced atazanavir exposure, reduced efficacy of atazanavir and development of resistance Details Esomeprazole Injection Atezolizumab Tecentriq Impaired efficacy of atezolizumab Details Esomeprazole Injection Belumosudil Rezurock Reduced belumosudil exposure Details Esomeprazole Injection Belzutifan Welireg Increased belzutifan exposure and an increased risk of belzutifan-related adverse reactions Details Esomeprazole Injection Benzphetamine Increased exposure to amphetamine Details Esomeprazole Injection Bosutinib Bosulif Reduced bosutinib exposure Details Esomeprazole Injection Cannabidiol Epidiolex Increased CYP2C19 substrate exposure and an increased risk of CYP2C19 substrate-related adverse reactions Details Esomeprazole Injection Capecitabine Xeloda Reduction in capecitabine efficacy Details Esomeprazole Injection Carbamazepine Carbatrol Reduced CYP2C19 substrate exposure and reduced efficacy of CYP2C19 substrate Details Esomeprazole Injection Cefuroxime Axetil Decreased cefuroxime axetil exposure Details Esomeprazole Injection Cilostazol Pletal® Increased cilostazol exposure Details Esomeprazole Injection Citalopram Celexa Increased citalopram exposure and an increased risk of QT interval prolongation Details Esomeprazole Injection Clopidogrel Plavix Reduced clopidogrel active metabolite exposure and reduced antiplatelet activity Details Esomeprazole Injection Dacomitinib Vizimpro Reduced dacomitinib exposure Details Esomeprazole Injection Dasatinib Phyrago Reduced dasatinib exposure Details Esomeprazole Injection Defactinib Reduced defactinib exposure and an reduced efficacy of defactinib Details Esomeprazole Injection Dextroamphetamine Dexedrine Increased exposure to amphetamine Details Esomeprazole Injection Digoxin Cardoxin® Increased digoxin exposure Details Esomeprazole Injection Erlotinib Tarceva Reduced erlotinib exposure Details Esomeprazole Injection Escitalopram Lexapro Increased escitalopram exposure Details Esomeprazole Injection Eslicarbazepine Acetate Aptiom Increased exposure of CYP2C19 substrates Details Esomeprazole Injection Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Esomeprazole Injection Gefitinib Iressa Decreased exposure of gefitinib Details Esomeprazole Injection Haloperidol Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Esomeprazole Injection Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details Esomeprazole Injection Ketoconazole Extina Reduced ketoconazole exposure and reduced efficacy of ketoconazole Details Esomeprazole Injection Ledipasvir Decreased ledipasvir exposure and loss of efficacy Details Esomeprazole Injection Lemborexant Dayvigo Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Esomeprazole Injection Levoketoconazole Recorlev Reduced levoketoconazole exposure Details Esomeprazole Injection Lisdexamfetamine Arynta Increased exposure to amphetamine Details Esomeprazole Injection Lomitapide Increased lomitapide exposure Details Esomeprazole Injection Lonafarnib Zokinvy Increased CYP2C19 substrate exposure and an increased risk of CYP2C19 substrate-related adverse effects Details Esomeprazole Injection Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Esomeprazole Injection Mavacamten Camzyos Increased mavacamten exposure, an increased risk of mavacamten-related adverse reactions, reduced esomeprazole exposure and reduce... Details Esomeprazole Injection Methadone Diskets Increased methadone exposure and an increased risk of opioid adverse effects Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.